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Review Article 


Marek’s disease: A global challenge to poultry health and productivity

Sri Mulyati, Imam Mustofa, Aswin Rafif Khairullah, Muhammad Khaliim Jati Kusala, Ima Fauziah, Riza Zainuddin Ahmad, Fitrine Ekawasti, Sri Suryatmiati Prihandani, Abdul Hadi Furqoni, Bantari Wisynu Kusuma Wardhani, Dea Anita Ariani Kurniasih, Andi Thafida Khalisa, Ikechukwu Benjamin Moses, Adeyinka Oye Akintunde, Bima Putra Pratama, Prima Puji Raharjo, Kartika Afrida Fauzia, Syahputra Wibowo.


Abstract
Marek’s disease is a neuropathic and lymphoproliferative viral condition that primarily affects chickens and occasionally affects quail and turkeys. It is caused by the Marek’s disease virus (MDV), a member of the family Herpesviridae, subfamily Alphaherpesvirinae, genus Mardivirus, which comprises three distinct species: MDV-1, MDV-2, and MDV-3 (herpesvirus of turkeys). Marek’s disease remains a significant global challenge despite the availability of vaccines, with outbreaks still occurring in many poultry-producing regions due to the evolving virulence of the virus and incomplete protection. The current literature provides abundant information on the etiology, pathogenesis, and control of Marek’s Disease; however, an up-to-date, comprehensive synthesis that integrates recent molecular insights, epidemiological patterns, and advanced control strategies is lacking. This review addresses this gap by systematically compiling and analyzing recent studies published in peer-reviewed journals, selected through database searches in PubMed, Scopus, and Web of Science using predefined inclusion and exclusion criteria. Key findings highlight the complexity of MDV pathogenesis, virus persistence in the poultry environment, and limitations of existing vaccines in achieving sterile immunity. The review also underscores the importance of combining vaccination with genetic selection and strict biosecurity to mitigate economic losses. Understanding these interconnected factors is crucial for guiding future research and improving disease management strategies in the poultry industry.

Key words: Marek’s disease Virus, biosecurity measures, Poultry health, Viral pathogenesis.


 
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How to Cite this Article
Pubmed Style

Mulyati S, Mustofa I, Khairullah AR, Kusala MKJ, Fauziah I, Ahmad RZ, Ekawasti F, Prihandani SS, Furqoni AH, Wardhani BWK, Kurniasih DAA, Khalisa AT, Moses IB, Akintunde AO, Pratama BP, Raharjo PP, Fauzia KA, Wibowo S. Marek’s disease: A global challenge to poultry health and productivity. Open Vet. J.. 2025; 15(10): 4797-4813. doi:10.5455/OVJ.2025.v15.i10.2

Web Style

Mulyati S, Mustofa I, Khairullah AR, Kusala MKJ, Fauziah I, Ahmad RZ, Ekawasti F, Prihandani SS, Furqoni AH, Wardhani BWK, Kurniasih DAA, Khalisa AT, Moses IB, Akintunde AO, Pratama BP, Raharjo PP, Fauzia KA, Wibowo S. Marek’s disease: A global challenge to poultry health and productivity. https://www.openveterinaryjournal.com/?mno=267956 [Access: October 31, 2025]. doi:10.5455/OVJ.2025.v15.i10.2

AMA (American Medical Association) Style

Mulyati S, Mustofa I, Khairullah AR, Kusala MKJ, Fauziah I, Ahmad RZ, Ekawasti F, Prihandani SS, Furqoni AH, Wardhani BWK, Kurniasih DAA, Khalisa AT, Moses IB, Akintunde AO, Pratama BP, Raharjo PP, Fauzia KA, Wibowo S. Marek’s disease: A global challenge to poultry health and productivity. Open Vet. J.. 2025; 15(10): 4797-4813. doi:10.5455/OVJ.2025.v15.i10.2


Vancouver/ICMJE Style

Mulyati S, Mustofa I, Khairullah AR, Kusala MKJ, Fauziah I, Ahmad RZ, Ekawasti F, Prihandani SS, Furqoni AH, Wardhani BWK, Kurniasih DAA, Khalisa AT, Moses IB, Akintunde AO, Pratama BP, Raharjo PP, Fauzia KA, Wibowo S. Marek’s disease: A global challenge to poultry health and productivity. Open Vet. J.. (2025), [cited October 31, 2025]; 15(10): 4797-4813. doi:10.5455/OVJ.2025.v15.i10.2


Harvard Style

Mulyati, S., Mustofa, . I., Khairullah, . A. R., Kusala, . M. K. J., Fauziah, . I., Ahmad, . R. Z., Ekawasti, . F., Prihandani, . S. S., Furqoni, . A. H., Wardhani, . B. W. K., Kurniasih, . D. A. A., Khalisa, . A. T., Moses, . I. B., Akintunde, . A. O., Pratama, . B. P., Raharjo, . P. P., Fauzia, . K. A. & Wibowo, . S. (2025) Marek’s disease: A global challenge to poultry health and productivity. Open Vet. J., 15 (10), 4797-4813. doi:10.5455/OVJ.2025.v15.i10.2


Turabian Style

Mulyati, Sri, Imam Mustofa, Aswin Rafif Khairullah, Muhammad Khaliim Jati Kusala, Ima Fauziah, Riza Zainuddin Ahmad, Fitrine Ekawasti, Sri Suryatmiati Prihandani, Abdul Hadi Furqoni, Bantari Wisynu Kusuma Wardhani, Dea Anita Ariani Kurniasih, Andi Thafida Khalisa, Ikechukwu Benjamin Moses, Adeyinka Oye Akintunde, Bima Putra Pratama, Prima Puji Raharjo, Kartika Afrida Fauzia, and Syahputra Wibowo. 2025. Marek’s disease: A global challenge to poultry health and productivity. Open Veterinary Journal, 15 (10), 4797-4813. doi:10.5455/OVJ.2025.v15.i10.2


Chicago Style

Mulyati, Sri, Imam Mustofa, Aswin Rafif Khairullah, Muhammad Khaliim Jati Kusala, Ima Fauziah, Riza Zainuddin Ahmad, Fitrine Ekawasti, Sri Suryatmiati Prihandani, Abdul Hadi Furqoni, Bantari Wisynu Kusuma Wardhani, Dea Anita Ariani Kurniasih, Andi Thafida Khalisa, Ikechukwu Benjamin Moses, Adeyinka Oye Akintunde, Bima Putra Pratama, Prima Puji Raharjo, Kartika Afrida Fauzia, and Syahputra Wibowo. "Marek’s disease: A global challenge to poultry health and productivity." Open Veterinary Journal 15 (2025), 4797-4813. doi:10.5455/OVJ.2025.v15.i10.2


MLA (The Modern Language Association) Style

Mulyati, Sri, Imam Mustofa, Aswin Rafif Khairullah, Muhammad Khaliim Jati Kusala, Ima Fauziah, Riza Zainuddin Ahmad, Fitrine Ekawasti, Sri Suryatmiati Prihandani, Abdul Hadi Furqoni, Bantari Wisynu Kusuma Wardhani, Dea Anita Ariani Kurniasih, Andi Thafida Khalisa, Ikechukwu Benjamin Moses, Adeyinka Oye Akintunde, Bima Putra Pratama, Prima Puji Raharjo, Kartika Afrida Fauzia, and Syahputra Wibowo. "Marek’s disease: A global challenge to poultry health and productivity." Open Veterinary Journal 15.10 (2025), 4797-4813. Print. doi:10.5455/OVJ.2025.v15.i10.2


APA (American Psychological Association) Style

Mulyati, S., Mustofa, . I., Khairullah, . A. R., Kusala, . M. K. J., Fauziah, . I., Ahmad, . R. Z., Ekawasti, . F., Prihandani, . S. S., Furqoni, . A. H., Wardhani, . B. W. K., Kurniasih, . D. A. A., Khalisa, . A. T., Moses, . I. B., Akintunde, . A. O., Pratama, . B. P., Raharjo, . P. P., Fauzia, . K. A. & Wibowo, . S. (2025) Marek’s disease: A global challenge to poultry health and productivity. Open Veterinary Journal, 15 (10), 4797-4813. doi:10.5455/OVJ.2025.v15.i10.2


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