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Studies on the antidiarrhoeal, antimicrobial and cytotoxic activities of ethanol-extracted leaves of yellow oleander (Thevetia peruviana)

M.m. Hassan1, *, A.k. Saha1, S.a. Khan1, A. Islam1, M. Mahabub-uz-zaman2 And S.s.u. Ahmed3.


Cited By:44

Abstract
This study screened the antidiarrhoeal, antimicrobial and cytotoxic effects of ethanol-extracted leaves of yellow oleander (Thevetia peruviana). The extract was tested against castor oil-induced diarrhoea in a model of albino rats and showed significant antidiarrhoeal activity (P<0.01). Disc diffusion technique was used to test the in vitro antibacterial activities of the extract and exhibited poor antibacterial activities against both Gram positive and Gram negative bacteria (mainly Bacillus sp). Ethanol-extracted leaves of yellow oleander showed narrow zone of inhibition in the bacterial lawns of Shigella flexineri, Salmonella typhi, Klebsiella sp, Staphylococcus aureus and Shigella sonnei. Cytotoxicty was determined against brine shrimp nauplii and LC50 of the plant extract was determined as 627.21�g/ml. The wide range of LC50 value denotes the safety effect of the extract.

Key words: Antidiarrhoeal, Antimicrobial, Cytotoxicity, Albino rats, Brine shrimp, Yellow oleander, LC50


 
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How to Cite this Article
Pubmed Style

Hassan M, , Saha A, Khan S, Islam A, Ahmed MMAS. Studies on the antidiarrhoeal, antimicrobial and cytotoxic activities of ethanol-extracted leaves of yellow oleander (Thevetia peruviana). Open Vet J. 2011; 1(0): 28-31. doi:10.5455/OVJ.2011.v1.i0.p28

Web Style

Hassan M, , Saha A, Khan S, Islam A, Ahmed MMAS. Studies on the antidiarrhoeal, antimicrobial and cytotoxic activities of ethanol-extracted leaves of yellow oleander (Thevetia peruviana). https://www.openveterinaryjournal.com/?mno=302656804 [Access: May 18, 2025]. doi:10.5455/OVJ.2011.v1.i0.p28

AMA (American Medical Association) Style

Hassan M, , Saha A, Khan S, Islam A, Ahmed MMAS. Studies on the antidiarrhoeal, antimicrobial and cytotoxic activities of ethanol-extracted leaves of yellow oleander (Thevetia peruviana). Open Vet J. 2011; 1(0): 28-31. doi:10.5455/OVJ.2011.v1.i0.p28


Vancouver/ICMJE Style

Hassan M, , Saha A, Khan S, Islam A, Ahmed MMAS. Studies on the antidiarrhoeal, antimicrobial and cytotoxic activities of ethanol-extracted leaves of yellow oleander (Thevetia peruviana). Open Vet J. (2011), [cited May 18, 2025]; 1(0): 28-31. doi:10.5455/OVJ.2011.v1.i0.p28


Harvard Style

Hassan, M., , ., Saha, . A., Khan, . S., Islam, . A. & Ahmed, . M. M. A. S. (2011) Studies on the antidiarrhoeal, antimicrobial and cytotoxic activities of ethanol-extracted leaves of yellow oleander (Thevetia peruviana). Open Vet J, 1 (0), 28-31. doi:10.5455/OVJ.2011.v1.i0.p28


Turabian Style

Hassan, M.m., , A.k. Saha, S.a. Khan, A. Islam, and M. Mahabub-uz-zaman And S.s.u. Ahmed. 2011. Studies on the antidiarrhoeal, antimicrobial and cytotoxic activities of ethanol-extracted leaves of yellow oleander (Thevetia peruviana). Open Veterinary Journal, 1 (0), 28-31. doi:10.5455/OVJ.2011.v1.i0.p28


Chicago Style

Hassan, M.m., , A.k. Saha, S.a. Khan, A. Islam, and M. Mahabub-uz-zaman And S.s.u. Ahmed. "Studies on the antidiarrhoeal, antimicrobial and cytotoxic activities of ethanol-extracted leaves of yellow oleander (Thevetia peruviana)." Open Veterinary Journal 1 (2011), 28-31. doi:10.5455/OVJ.2011.v1.i0.p28


MLA (The Modern Language Association) Style

Hassan, M.m., , A.k. Saha, S.a. Khan, A. Islam, and M. Mahabub-uz-zaman And S.s.u. Ahmed. "Studies on the antidiarrhoeal, antimicrobial and cytotoxic activities of ethanol-extracted leaves of yellow oleander (Thevetia peruviana)." Open Veterinary Journal 1.0 (2011), 28-31. Print. doi:10.5455/OVJ.2011.v1.i0.p28


APA (American Psychological Association) Style

Hassan, M., , ., Saha, . A., Khan, . S., Islam, . A. & Ahmed, . M. M. A. S. (2011) Studies on the antidiarrhoeal, antimicrobial and cytotoxic activities of ethanol-extracted leaves of yellow oleander (Thevetia peruviana). Open Veterinary Journal, 1 (0), 28-31. doi:10.5455/OVJ.2011.v1.i0.p28


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