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2025, Vol: 15, Issue: 4
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Original Article


Effects of topical flurbiprofen sodium, diclofenac sodium, ketorolac tromethamine and benzalkonium chloride on corneal sensitivity in normal dogs

Raquel De Araújo Cantarella, Fabiano Montiani-ferreira, Juliana Kravetz De Oliveira, Daniel M Dorbandt.


Cited By:11

Abstract
To evaluate corneal sensitivity by using the Cochet-Bonnet® esthesiometer in normal canine eyes at different time points following instillation of three different topical non-steroidal anti-inflammatory drugs (flurbiprofen sodium 0.03%, diclofenac sodium 0.1% and ketorolac tromethamine 0.5%) and benzalkonium chloride 0.01%. Six healthy mixed breed dogs from the same litter were used in two different stages. First, one drop of flurbiprofen sodium 0.03% and diclofenac sodium 0.1% in each eye; second, one drop of ketorolac tromethamine 0.5% and benzalkonium chloride 0.01% in each eye. Baseline esthesiometry was obtained before eye drop application and every 15 minutes thereafter until a total of 105 minutes of evaluation time. A one-week interval was allowed between the two treatment phases. Statistical analysis was used to compare means according to time of evaluation and drug used. Diclofenac sodium 0.1% decreased corneal sensitivity at 75 and 90 minutes (P > 0.015) with possible interference on neuronal nociceptive activity and analgesic effect while ketorolac tromethamine 0.5% did not show any variation for esthesiometry means along the evaluation. Flurbiprofen sodium 0.03% resulted in increased esthesiometry values 30 minutes after instillation (P > 0.013), increasing corneal sensitivity and possibly producing a greater irritant corneal effect over its analgesic properties. Benzalkonium chloride 0.01% significantly increased corneal sensitivity at 15 minutes of evaluation (P > 0.001), most likely resulting from its irritating effect. Esthesiometry did not allow a definite conclusion over the analgesic effect of the NSAIDs tested; however it was effective in detecting fluctuations in corneal sensitivity.

Key words: cornea, Cochet-Bonnet, nociceptors, NSAID


 
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How to Cite this Article
Pubmed Style

Cantarella RDA, Montiani-ferreira F, Oliveira JKD, Dorbandt DM. Effects of topical flurbiprofen sodium, diclofenac sodium, ketorolac tromethamine and benzalkonium chloride on corneal sensitivity in normal dogs. Open Vet J. 2017; 7(3): 254-260. doi:10.4314/ovj.v7i3.9

Web Style

Cantarella RDA, Montiani-ferreira F, Oliveira JKD, Dorbandt DM. Effects of topical flurbiprofen sodium, diclofenac sodium, ketorolac tromethamine and benzalkonium chloride on corneal sensitivity in normal dogs. https://www.openveterinaryjournal.com/?mno=244638 [Access: May 04, 2025]. doi:10.4314/ovj.v7i3.9

AMA (American Medical Association) Style

Cantarella RDA, Montiani-ferreira F, Oliveira JKD, Dorbandt DM. Effects of topical flurbiprofen sodium, diclofenac sodium, ketorolac tromethamine and benzalkonium chloride on corneal sensitivity in normal dogs. Open Vet J. 2017; 7(3): 254-260. doi:10.4314/ovj.v7i3.9


Vancouver/ICMJE Style

Cantarella RDA, Montiani-ferreira F, Oliveira JKD, Dorbandt DM. Effects of topical flurbiprofen sodium, diclofenac sodium, ketorolac tromethamine and benzalkonium chloride on corneal sensitivity in normal dogs. Open Vet J. (2017), [cited May 04, 2025]; 7(3): 254-260. doi:10.4314/ovj.v7i3.9


Harvard Style

Cantarella, R. D. A., Montiani-ferreira, . F., Oliveira, . J. K. D. & Dorbandt, . D. M. (2017) Effects of topical flurbiprofen sodium, diclofenac sodium, ketorolac tromethamine and benzalkonium chloride on corneal sensitivity in normal dogs. Open Vet J, 7 (3), 254-260. doi:10.4314/ovj.v7i3.9


Turabian Style

Cantarella, Raquel De Araújo, Fabiano Montiani-ferreira, Juliana Kravetz De Oliveira, and Daniel M Dorbandt. 2017. Effects of topical flurbiprofen sodium, diclofenac sodium, ketorolac tromethamine and benzalkonium chloride on corneal sensitivity in normal dogs. Open Veterinary Journal, 7 (3), 254-260. doi:10.4314/ovj.v7i3.9


Chicago Style

Cantarella, Raquel De Araújo, Fabiano Montiani-ferreira, Juliana Kravetz De Oliveira, and Daniel M Dorbandt. "Effects of topical flurbiprofen sodium, diclofenac sodium, ketorolac tromethamine and benzalkonium chloride on corneal sensitivity in normal dogs." Open Veterinary Journal 7 (2017), 254-260. doi:10.4314/ovj.v7i3.9


MLA (The Modern Language Association) Style

Cantarella, Raquel De Araújo, Fabiano Montiani-ferreira, Juliana Kravetz De Oliveira, and Daniel M Dorbandt. "Effects of topical flurbiprofen sodium, diclofenac sodium, ketorolac tromethamine and benzalkonium chloride on corneal sensitivity in normal dogs." Open Veterinary Journal 7.3 (2017), 254-260. Print. doi:10.4314/ovj.v7i3.9


APA (American Psychological Association) Style

Cantarella, R. D. A., Montiani-ferreira, . F., Oliveira, . J. K. D. & Dorbandt, . D. M. (2017) Effects of topical flurbiprofen sodium, diclofenac sodium, ketorolac tromethamine and benzalkonium chloride on corneal sensitivity in normal dogs. Open Veterinary Journal, 7 (3), 254-260. doi:10.4314/ovj.v7i3.9


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