E-ISSN 2218-6050 | ISSN 2226-4485
 

Research Article


Monitoring of bone matrix acidification by TRAP and ERK biomarkers in the chronic hypercholesterolemia male rats

Duaa Raad Abd-Al-Ameer, Wefak Albazi, Hayder Ali Muhammed.


Abstract
Background:
Hypercholesterolemia is frequently linked to an elevated risk of cardiovascular diseases, including heart attacks and strokes. Additionally, it could be connected to a higher susceptibility to osteoporosis. Hypercholesterolemia can stimulate differentiation and activity of osteoclasts, leading to enhanced bone reabsorption and a subsequent net loss of bone tissue.
Aim:
The purpose of this study was to examine the influence of a high cholesterol diet on osteoporosis in male rats with differences in biological and oxidative indicators in hypercholesterolemia diet in male rat.
Method:
The samples in this study were twenty male rats, ranging between 1.5 and 2 months, were separated into two groups. In one group, 10 rats were fed a regular diet, while in another group, 10 rats were fed a high cholesterol diet (2%) over the course of 8 weeks. Samples of blood were obtained at the last stage of the experiment. to calculate physiological and biological markers including ERK, TRAP, hormones, MDA, and GSH.
Results:
The results of this study demonstrated a decrease in glutathione levels, an increase in extracellular signal-regulated kinase levels (ERK), no significant change in serum TRAP levels, an increase in Malondialdehyde levels in the blood, and elevated levels of parathyroid hormone, Calcitonin, and Vitamin D in the cholesterol group.
Conclusion:
An increased oxidative stress, altered signaling, and disruptions in calcium/bone metabolism associated with cholesterol-related condition and monitoring biomarker ERK can provide valuable information about disease progression.

Key words: Hypercholesterolemia, Osteoporosis, ERK, TRAP


 
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How to Cite this Article
Pubmed Style

Abd-Al-Ameer DR, Albazi W, Muhammed HA. Monitoring of bone matrix acidification by TRAP and ERK biomarkers in the chronic hypercholesterolemia male rats. Open Vet J. 2024; 14(8): 1836-1842. doi:10.5455/OVJ.2024.v14.i8.11


Web Style

Abd-Al-Ameer DR, Albazi W, Muhammed HA. Monitoring of bone matrix acidification by TRAP and ERK biomarkers in the chronic hypercholesterolemia male rats. https://www.openveterinaryjournal.com/?mno=196924 [Access: October 04, 2024]. doi:10.5455/OVJ.2024.v14.i8.11


AMA (American Medical Association) Style

Abd-Al-Ameer DR, Albazi W, Muhammed HA. Monitoring of bone matrix acidification by TRAP and ERK biomarkers in the chronic hypercholesterolemia male rats. Open Vet J. 2024; 14(8): 1836-1842. doi:10.5455/OVJ.2024.v14.i8.11



Vancouver/ICMJE Style

Abd-Al-Ameer DR, Albazi W, Muhammed HA. Monitoring of bone matrix acidification by TRAP and ERK biomarkers in the chronic hypercholesterolemia male rats. Open Vet J. (2024), [cited October 04, 2024]; 14(8): 1836-1842. doi:10.5455/OVJ.2024.v14.i8.11



Harvard Style

Abd-Al-Ameer, D. R., Albazi, . W. & Muhammed, . H. A. (2024) Monitoring of bone matrix acidification by TRAP and ERK biomarkers in the chronic hypercholesterolemia male rats. Open Vet J, 14 (8), 1836-1842. doi:10.5455/OVJ.2024.v14.i8.11



Turabian Style

Abd-Al-Ameer, Duaa Raad, Wefak Albazi, and Hayder Ali Muhammed. 2024. Monitoring of bone matrix acidification by TRAP and ERK biomarkers in the chronic hypercholesterolemia male rats. Open Veterinary Journal, 14 (8), 1836-1842. doi:10.5455/OVJ.2024.v14.i8.11



Chicago Style

Abd-Al-Ameer, Duaa Raad, Wefak Albazi, and Hayder Ali Muhammed. "Monitoring of bone matrix acidification by TRAP and ERK biomarkers in the chronic hypercholesterolemia male rats." Open Veterinary Journal 14 (2024), 1836-1842. doi:10.5455/OVJ.2024.v14.i8.11



MLA (The Modern Language Association) Style

Abd-Al-Ameer, Duaa Raad, Wefak Albazi, and Hayder Ali Muhammed. "Monitoring of bone matrix acidification by TRAP and ERK biomarkers in the chronic hypercholesterolemia male rats." Open Veterinary Journal 14.8 (2024), 1836-1842. Print. doi:10.5455/OVJ.2024.v14.i8.11



APA (American Psychological Association) Style

Abd-Al-Ameer, D. R., Albazi, . W. & Muhammed, . H. A. (2024) Monitoring of bone matrix acidification by TRAP and ERK biomarkers in the chronic hypercholesterolemia male rats. Open Veterinary Journal, 14 (8), 1836-1842. doi:10.5455/OVJ.2024.v14.i8.11