Polymorphism of the MFGE8/HinfI Gene and its Association with Pasundan Heifers’ Performance Traits

Abdullah Baharun; Fera Indah Sari; Widya Pintaka Bayu Putra; Annisa Rahmi; Deden Sudrajat; Raden Iis Arifiantini; Tulus Maulana; Hartati Hartati; Athhar Manabi Diansyah; Vidi Wulandari; Erna Nur Rizki; Wilmientje Marlene Nalley; Thobela Louis Tyasi

doi:10.5455/OVJ.2026.v16.i9.66

2026, Vol: 16, Issue: 9

16 / 9Current Issue Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

OVJ Manuscript Submissio Form
Title Page
mainarticle_template

« Previous Article

Research Article

Open Vet. J.. 2026; 16(9): 6634-6641

doi: 10.5455/OVJ.2026.v16.i9.66

Polymorphism of the MFGE8/HinfI Gene and its Association with Pasundan Heifers’ Performance Traits

Abdullah Baharun, Fera Indah Sari, Widya Pintaka Bayu Putra, Annisa Rahmi, Deden Sudrajat, Raden Iis Arifiantini, Tulus Maulana, Hartati Hartati, Athhar Manabi Diansyah, Vidi Wulandari, Erna Nur Rizki, Wilmientje Marlene Nalley, Thobela Louis Tyasi.

Abstract
Background:
Pasundan cattle (Bos indicus) are an indigenous beef cattle breed from West Java, Indonesia, with potential value for genetic improvement programs. The MFGE8 gene has been implicated in various biological processes. It may serve as a candidate gene for growth-related traits in cattle.

Aim:
This study aimed to identify the MFGE8/HinfI gene polymorphism and evaluate its association with performance traits in young Pasundan female cattle (heifers).

Methods:
A total of 36 Pasundan heifers aged 14–18 months from the breeding center at Cijeungjing, West Java, Indonesia, were used in this study. Body weight and body measurements, including body length, wither height, and chest girth, were recorded for association analysis. Genotyping of the MFGE8/HinfI locus (g.9929T>G) located in intron 6 was performed using PCR-RFLP. The genetic diversity parameters and associations between genotypes and performance traits were subsequently analyzed.

Results:
The MFGE8/HinfI locus was polymorphic in the Pasundan cattle population and exhibited a moderate PIC (PIC = 0.36). The frequency of the T allele (0.60) was higher than that of the G allele (0.40). However, the genotype distribution significantly deviated from the Hardy–Weinberg equilibrium (χ² = 11.25). Hence, the previous selection in the Pasundan cattle under study affected the genetic diversity in an investigated locus. Association analysis revealed that the MFGE8/HinfI polymorphism had no significant effect (p > 0.05) on body weight, body length, wither height, or chest girth in the studied animals.

Conclusion:
The MFGE8/HinfI gene is polymorphic and possesses moderate genetic informativeness in Pasundan cattle. However, polymorphisms were not significantly associated with performance traits in Pasundan heifers. To validate these findings and assess the potential application of MFGE8 as a molecular marker in marker-assisted selection programs for Pasundan cattle, further studies using larger populations are required.

Key words: MFGE8 gene; Pasundan cattle; PCR-RFLP; Performance traits; Polymorphism.

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Abdullah Baharun Articles by Fera Indah Sari Articles by Widya Pintaka Bayu Putra Articles by Annisa Rahmi Articles by Deden Sudrajat Articles by Raden Iis Arifiantini Articles by Tulus Maulana Articles by Hartati Hartati Articles by Athhar Manabi Diansyah Articles by Vidi Wulandari Articles by Erna Nur Rizki Articles by Wilmientje Marlene Nalley Articles by Thobela Louis Tyasi
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Baharun A, Sari FI, Putra WPB, Rahmi A, Sudrajat D, Arifiantini RI, Maulana T, Hartati H, Diansyah AM, Wulandari V, Rizki EN, Nalley WM, Tyasi TL. Polymorphism of the MFGE8/HinfI Gene and its Association with Pasundan Heifers’ Performance Traits. doi:10.5455/OVJ.2026.v16.i9.66

Web Style

Baharun A, Sari FI, Putra WPB, Rahmi A, Sudrajat D, Arifiantini RI, Maulana T, Hartati H, Diansyah AM, Wulandari V, Rizki EN, Nalley WM, Tyasi TL. Polymorphism of the MFGE8/HinfI Gene and its Association with Pasundan Heifers’ Performance Traits. https://www.openveterinaryjournal.com/?mno=324884 [Access: September 30, 2026]. doi:10.5455/OVJ.2026.v16.i9.66

AMA (American Medical Association) Style

Baharun A, Sari FI, Putra WPB, Rahmi A, Sudrajat D, Arifiantini RI, Maulana T, Hartati H, Diansyah AM, Wulandari V, Rizki EN, Nalley WM, Tyasi TL. Polymorphism of the MFGE8/HinfI Gene and its Association with Pasundan Heifers’ Performance Traits. doi:10.5455/OVJ.2026.v16.i9.66

Vancouver/ICMJE Style

Harvard Style

Baharun, A., Sari, . F. I., Putra, . W. P. B., Rahmi, . A., Sudrajat, . D., Arifiantini, . R. I., Maulana, . T., Hartati, . H., Diansyah, . A. M., Wulandari, . V., Rizki, . E. N., Nalley, . W. M. & Tyasi, . T. L. (2026) Polymorphism of the MFGE8/HinfI Gene and its Association with Pasundan Heifers’ Performance Traits. doi:10.5455/OVJ.2026.v16.i9.66

Turabian Style

Baharun, Abdullah, Fera Indah Sari, Widya Pintaka Bayu Putra, Annisa Rahmi, Deden Sudrajat, Raden Iis Arifiantini, Tulus Maulana, Hartati Hartati, Athhar Manabi Diansyah, Vidi Wulandari, Erna Nur Rizki, Wilmientje Marlene Nalley, and Thobela Louis Tyasi. 2026. Polymorphism of the MFGE8/HinfI Gene and its Association with Pasundan Heifers’ Performance Traits. doi:10.5455/OVJ.2026.v16.i9.66

Chicago Style

Baharun, Abdullah, Fera Indah Sari, Widya Pintaka Bayu Putra, Annisa Rahmi, Deden Sudrajat, Raden Iis Arifiantini, Tulus Maulana, Hartati Hartati, Athhar Manabi Diansyah, Vidi Wulandari, Erna Nur Rizki, Wilmientje Marlene Nalley, and Thobela Louis Tyasi. "Polymorphism of the MFGE8/HinfI Gene and its Association with Pasundan Heifers’ Performance Traits." doi:10.5455/OVJ.2026.v16.i9.66

MLA (The Modern Language Association) Style

Baharun, Abdullah, Fera Indah Sari, Widya Pintaka Bayu Putra, Annisa Rahmi, Deden Sudrajat, Raden Iis Arifiantini, Tulus Maulana, Hartati Hartati, Athhar Manabi Diansyah, Vidi Wulandari, Erna Nur Rizki, Wilmientje Marlene Nalley, and Thobela Louis Tyasi. "Polymorphism of the MFGE8/HinfI Gene and its Association with Pasundan Heifers’ Performance Traits." doi:10.5455/OVJ.2026.v16.i9.66

APA (American Psychological Association) Style

About Open Veterinary Journal

About the JournalOpen Veterinary Journal (OVJ) is an international, peer-reviewed, open-access journal dedicated to the publication and dissemination of h ... Read more.

For best results, please use Internet Explorer or Google Chrome.

Contact Information

All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes

Editor-in-Chief

Open Veterinary Journal

Faculty of Veterinary Medicine, University of Tripoli

P.O. Box 13662, Tripoli, Libya

Email: ibrahim.eldaghayes@vetmed.edu.ly

About Open Veterinary Journal

Contact Information

How to cite this article