E-ISSN 2218-6050 | ISSN 2226-4485
 
2026, Vol: 16, Issue: 3
16 / 3Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

OVJ Manuscript Submissio Form
Title Page
mainarticle_template

Research Article


Anti-Psoriatic activity of Coffee liberica pulp extract on Imiquimod-induced Psoriasis-like dermatitis in Balb/C mice

Mishalini Vijayakumaran, Monisha Thanka Velu, Azrina Zainal Abidin, Hasnah Bahari, Fezah Othman, Goh Khang Wen, Mahardian Rahmadi, Santhra Segaran Balan.


Abstract
Background:
Psoriasis, also known as PsO, is a persistent skin disorder that results in erythematous, indurated, scaly, itchy, and often painful plaques. Although conventional medicine has been employed to treat psoriasis, it may cause adverse effects owing to its long-term use. Consequently, alternative medicine has become a popular option to address this issue. Coffee liberica pulp, a commonly overlooked waste product, has been found to have numerous benefits for humans.

Aim:
This study investigated the effectiveness of Liberia coffee pulp extract using an imiquimod (IMQ) -induced mouse model that replicated several features of psoriasis in humans.

Methods:
The study involved applying imiquimod (IMQ) cream and other topical treatments to the shaved dorsal skin of mice. The psoriasis Area and Severity Index (PASI) score, body weight, organ weight, expression of interleukins in the skin and serum, and full blood count were measured.

Results:
The results showed significant changes (p<0.05) skin weights in negative control group compare other group. No significant changes in other organ weight in any groups. However, the full blood count revealed significant changes (p<0.05) in haemoglobin and white blood cell counts. Interleukin 17a, interleukin 22, and interleukin 23 levels also showed significant differences (p<0.05) between the positive and treatment groups.

Conclusion:
This study found that coffee liberica pulp has anti-inflammatory and antioxidant properties that help reduce skin inflammation. These findings suggest that coffee liberica is a cost-effective source of natural antioxidants that can be used to alleviate psoriasis.

Key words: Psoriasis; Liberica coffee pulp; Imiquimod; Anti-psoriatic activity; Psoriasis Area and Severity Index (PASI) score.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Mishalini Vijayakumaran
Articles by Monisha Thanka Velu
Articles by Azrina Zainal Abidin
Articles by Hasnah Bahari
Articles by Fezah Othman
Articles by Goh Khang Wen
Articles by Mahardian Rahmadi
Articles by Santhra Segaran Balan
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Vijayakumaran M, Velu MT, Abidin AZ, Bahari H, Othman F, Wen GK, Rahmadi M, Balan SS. Anti-Psoriatic activity of Coffee liberica pulp extract on Imiquimod-induced Psoriasis-like dermatitis in Balb/C mice. Open Vet. J.. 2026; 16(3): 1725-1733. doi:10.5455/OVJ.2026.v16.i3.30

Web Style

Vijayakumaran M, Velu MT, Abidin AZ, Bahari H, Othman F, Wen GK, Rahmadi M, Balan SS. Anti-Psoriatic activity of Coffee liberica pulp extract on Imiquimod-induced Psoriasis-like dermatitis in Balb/C mice. https://www.openveterinaryjournal.com/?mno=283305 [Access: March 31, 2026]. doi:10.5455/OVJ.2026.v16.i3.30

AMA (American Medical Association) Style

Vijayakumaran M, Velu MT, Abidin AZ, Bahari H, Othman F, Wen GK, Rahmadi M, Balan SS. Anti-Psoriatic activity of Coffee liberica pulp extract on Imiquimod-induced Psoriasis-like dermatitis in Balb/C mice. Open Vet. J.. 2026; 16(3): 1725-1733. doi:10.5455/OVJ.2026.v16.i3.30


Vancouver/ICMJE Style

Vijayakumaran M, Velu MT, Abidin AZ, Bahari H, Othman F, Wen GK, Rahmadi M, Balan SS. Anti-Psoriatic activity of Coffee liberica pulp extract on Imiquimod-induced Psoriasis-like dermatitis in Balb/C mice. Open Vet. J.. (2026), [cited March 31, 2026]; 16(3): 1725-1733. doi:10.5455/OVJ.2026.v16.i3.30


Harvard Style

Vijayakumaran, M., Velu, . M. T., Abidin, . A. Z., Bahari, . H., Othman, . F., Wen, . G. K., Rahmadi, . M. & Balan, . S. S. (2026) Anti-Psoriatic activity of Coffee liberica pulp extract on Imiquimod-induced Psoriasis-like dermatitis in Balb/C mice. Open Vet. J., 16 (3), 1725-1733. doi:10.5455/OVJ.2026.v16.i3.30


Turabian Style

Vijayakumaran, Mishalini, Monisha Thanka Velu, Azrina Zainal Abidin, Hasnah Bahari, Fezah Othman, Goh Khang Wen, Mahardian Rahmadi, and Santhra Segaran Balan. 2026. Anti-Psoriatic activity of Coffee liberica pulp extract on Imiquimod-induced Psoriasis-like dermatitis in Balb/C mice. Open Veterinary Journal, 16 (3), 1725-1733. doi:10.5455/OVJ.2026.v16.i3.30


Chicago Style

Vijayakumaran, Mishalini, Monisha Thanka Velu, Azrina Zainal Abidin, Hasnah Bahari, Fezah Othman, Goh Khang Wen, Mahardian Rahmadi, and Santhra Segaran Balan. "Anti-Psoriatic activity of Coffee liberica pulp extract on Imiquimod-induced Psoriasis-like dermatitis in Balb/C mice." Open Veterinary Journal 16 (2026), 1725-1733. doi:10.5455/OVJ.2026.v16.i3.30


MLA (The Modern Language Association) Style

Vijayakumaran, Mishalini, Monisha Thanka Velu, Azrina Zainal Abidin, Hasnah Bahari, Fezah Othman, Goh Khang Wen, Mahardian Rahmadi, and Santhra Segaran Balan. "Anti-Psoriatic activity of Coffee liberica pulp extract on Imiquimod-induced Psoriasis-like dermatitis in Balb/C mice." Open Veterinary Journal 16.3 (2026), 1725-1733. Print. doi:10.5455/OVJ.2026.v16.i3.30


APA (American Psychological Association) Style

Vijayakumaran, M., Velu, . M. T., Abidin, . A. Z., Bahari, . H., Othman, . F., Wen, . G. K., Rahmadi, . M. & Balan, . S. S. (2026) Anti-Psoriatic activity of Coffee liberica pulp extract on Imiquimod-induced Psoriasis-like dermatitis in Balb/C mice. Open Veterinary Journal, 16 (3), 1725-1733. doi:10.5455/OVJ.2026.v16.i3.30


Author LoginReviewer LoginAbout PublisherOpen Access PolicyEditorial Review PolicyEditorial & Peer Review ProcessPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Corrections, Retractions & Expressions of ConcernDigital Archiving & Preservation PoliciesTerms of UseLicense InformationCopyright Information

About Open Veterinary Journal

Open Veterinary Journal provides a fast track coupled with high quality peer review process for original research articles, review articles, short communi ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes: Editor-in-Chief

Open Veterinary Journal

Faculty of Veterinary Medicine, University of Tripoli

P.O. Box 13662, Tripoli, Libya

and


Eldaghayes Publisher

www.eldaghayes.com 

Emails: ibrahim.eldaghayes@vetmed.edu.ly

info@eldaghayes.com