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Research Article


Ozonized sunflower oil as an integrative therapy for feline sporotrichosis: a randomized clinical trial

Lucile S. L. Baía, Beni J. M. Chaúque, Régis A. Zanette.


Abstract
Background:
Feline sporotrichosis, primarily caused by Sporothrix brasiliensis, is a zoonotic fungal infection with limited therapeutic options.

Aim:
This study evaluated the efficacy of ozonized sunflower oil (OSO) as an adjunct to itraconazole (ITZ) in 50 cats with sporotrichosis.

Methods:
Animals were randomized into two groups: ITZ alone (100 mg/cat once daily, n = 25) and ITZ plus topical OSO (700 meq/kg peroxide index, once daily, n = 25). Primary outcomes (wound healing time) and secondary outcomes (relapse rate) were assessed over 120 days.

Results:
Although the healing times were similar (ITZ: 29.04 ± 20.43 days; ITZ + OSO: 28.95 ± 11.41 days; p = 0.986), the ITZ + OSO group showed lower relapse rates (19.05% vs. 47.06%, p = 0.135) and delayed recurrence (48.67 vs. 27.62 days, p = 0.142). Notably, no relapses occurred in cats positive for feline immunodeficiency virus treated with ITZ + OSO (p = 0.0027).

Conclusion:
The immunomodulatory and antifungal properties of OSO may enhance therapeutic outcomes, particularly in immunocompromised animals.

Key words: Sporotrichosis; Itraconazole; Ozonized sunflower oil; Integrative therapy; Feline.


 
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How to Cite this Article
Pubmed Style

Baía LSL, Chaúque BJM, Zanette RA. Ozonized sunflower oil as an integrative therapy for feline sporotrichosis: a randomized clinical trial. Open Vet. J.. 2025; 15(12): 6373-6378. doi:10.5455/OVJ.2025.v15.i12.21

Web Style

Baía LSL, Chaúque BJM, Zanette RA. Ozonized sunflower oil as an integrative therapy for feline sporotrichosis: a randomized clinical trial. https://www.openveterinaryjournal.com/?mno=274152 [Access: December 31, 2025]. doi:10.5455/OVJ.2025.v15.i12.21

AMA (American Medical Association) Style

Baía LSL, Chaúque BJM, Zanette RA. Ozonized sunflower oil as an integrative therapy for feline sporotrichosis: a randomized clinical trial. Open Vet. J.. 2025; 15(12): 6373-6378. doi:10.5455/OVJ.2025.v15.i12.21


Vancouver/ICMJE Style

Baía LSL, Chaúque BJM, Zanette RA. Ozonized sunflower oil as an integrative therapy for feline sporotrichosis: a randomized clinical trial. Open Vet. J.. (2025), [cited December 31, 2025]; 15(12): 6373-6378. doi:10.5455/OVJ.2025.v15.i12.21


Harvard Style

Baía, L. S. L., Chaúque, . B. J. M. & Zanette, . R. A. (2025) Ozonized sunflower oil as an integrative therapy for feline sporotrichosis: a randomized clinical trial. Open Vet. J., 15 (12), 6373-6378. doi:10.5455/OVJ.2025.v15.i12.21


Turabian Style

Baía, Lucile S. L., Beni J. M. Chaúque, and Régis A. Zanette. 2025. Ozonized sunflower oil as an integrative therapy for feline sporotrichosis: a randomized clinical trial. Open Veterinary Journal, 15 (12), 6373-6378. doi:10.5455/OVJ.2025.v15.i12.21


Chicago Style

Baía, Lucile S. L., Beni J. M. Chaúque, and Régis A. Zanette. "Ozonized sunflower oil as an integrative therapy for feline sporotrichosis: a randomized clinical trial." Open Veterinary Journal 15 (2025), 6373-6378. doi:10.5455/OVJ.2025.v15.i12.21


MLA (The Modern Language Association) Style

Baía, Lucile S. L., Beni J. M. Chaúque, and Régis A. Zanette. "Ozonized sunflower oil as an integrative therapy for feline sporotrichosis: a randomized clinical trial." Open Veterinary Journal 15.12 (2025), 6373-6378. Print. doi:10.5455/OVJ.2025.v15.i12.21


APA (American Psychological Association) Style

Baía, L. S. L., Chaúque, . B. J. M. & Zanette, . R. A. (2025) Ozonized sunflower oil as an integrative therapy for feline sporotrichosis: a randomized clinical trial. Open Veterinary Journal, 15 (12), 6373-6378. doi:10.5455/OVJ.2025.v15.i12.21


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