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2025, Vol: 15, Issue: 4
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Case Report


MULTIPLE MYELOMA IN AN AMUR TIGER (PANTHERA TIGRIS ALTAICA)

Alison Marie Lee, Naomi Guppy, John Bainbridge, Hanne Jahns.


Cited By:3

Abstract
The Amur tiger (Panthera tigris altaica) is an endangered tiger subspecies. An adult zoo-bred female was found collapsed, and died despite supportive treatment. Hematology and biochemistry showed pancytopenia and hyperglobulinemia, and serum protein electrophoresis revealed a monoclonal band in the β-globulin region. Necropsy demonstrated hemoabdomen, multifocal lytic bone marrow lesions, splenomegaly, and hemorrhagic hepatic nodules, with left medial lobe rupture. There were mutifocal hemorrhages in the subcutis, lung, epicardium, and intestinal mucosa. Histopathology demonstrated plasmacytoid cells infiltrating the bone marrow, liver and spleen, and circulating within blood vessels. On immunohistochemistry, cell infiltrates of the three tissues were positive for λ light chains, bone marrow infiltrates were positive for MUM-1 and bone marrow and spleen infiltrates were positive for CD20. These findings indicate that this animal died of hemoabdomen subsequent to multiple myeloma. This is the first time this disease has been reported in a tiger.

Key words: Amur tiger, immunohistochemistry, multiple myeloma, serum protein electrophoresis, Pantera tigris altaica


 
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How to Cite this Article
Pubmed Style

Lee AM, Guppy N, Bainbridge J, Jahns H. MULTIPLE MYELOMA IN AN AMUR TIGER (PANTHERA TIGRIS ALTAICA). Open Vet J. 2017; 7(4): 300-305. doi:10.4314/ovj.v7i4.2

Web Style

Lee AM, Guppy N, Bainbridge J, Jahns H. MULTIPLE MYELOMA IN AN AMUR TIGER (PANTHERA TIGRIS ALTAICA). https://www.openveterinaryjournal.com/?mno=271613 [Access: May 01, 2025]. doi:10.4314/ovj.v7i4.2

AMA (American Medical Association) Style

Lee AM, Guppy N, Bainbridge J, Jahns H. MULTIPLE MYELOMA IN AN AMUR TIGER (PANTHERA TIGRIS ALTAICA). Open Vet J. 2017; 7(4): 300-305. doi:10.4314/ovj.v7i4.2


Vancouver/ICMJE Style

Lee AM, Guppy N, Bainbridge J, Jahns H. MULTIPLE MYELOMA IN AN AMUR TIGER (PANTHERA TIGRIS ALTAICA). Open Vet J. (2017), [cited May 01, 2025]; 7(4): 300-305. doi:10.4314/ovj.v7i4.2


Harvard Style

Lee, A. M., Guppy, . N., Bainbridge, . J. & Jahns, . H. (2017) MULTIPLE MYELOMA IN AN AMUR TIGER (PANTHERA TIGRIS ALTAICA). Open Vet J, 7 (4), 300-305. doi:10.4314/ovj.v7i4.2


Turabian Style

Lee, Alison Marie, Naomi Guppy, John Bainbridge, and Hanne Jahns. 2017. MULTIPLE MYELOMA IN AN AMUR TIGER (PANTHERA TIGRIS ALTAICA). Open Veterinary Journal, 7 (4), 300-305. doi:10.4314/ovj.v7i4.2


Chicago Style

Lee, Alison Marie, Naomi Guppy, John Bainbridge, and Hanne Jahns. "MULTIPLE MYELOMA IN AN AMUR TIGER (PANTHERA TIGRIS ALTAICA)." Open Veterinary Journal 7 (2017), 300-305. doi:10.4314/ovj.v7i4.2


MLA (The Modern Language Association) Style

Lee, Alison Marie, Naomi Guppy, John Bainbridge, and Hanne Jahns. "MULTIPLE MYELOMA IN AN AMUR TIGER (PANTHERA TIGRIS ALTAICA)." Open Veterinary Journal 7.4 (2017), 300-305. Print. doi:10.4314/ovj.v7i4.2


APA (American Psychological Association) Style

Lee, A. M., Guppy, . N., Bainbridge, . J. & Jahns, . H. (2017) MULTIPLE MYELOMA IN AN AMUR TIGER (PANTHERA TIGRIS ALTAICA). Open Veterinary Journal, 7 (4), 300-305. doi:10.4314/ovj.v7i4.2


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