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Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats

L.A. Denzoin Vulcano1,*, O. Confalonieri2, R. Franci2, M.O. Tapia1 and A.L. Soraci1.


Abstract
Acetaminophen (APAP) administration results in hepatotoxicity and hematotoxicity in cats. The response to three different treatments against APAP poisoning was evaluated. Free glutathione (GSH) (200mg/kg), niosomal GSH (14 mg/kg) and free amino acids (180 mg/kg of N-acetylcysteine and 280 mg/kg of methionine) were administered to cats that were intoxicated with APAP (a single dose of 150 mg/kg, p.o.). Serum concentration of alanine aminotransferase (ALT) along with serum, liver and erythrocyte concentration of GSH and methemoglobin percentage were measured before and 4, 24 and 72 hours after APAP administration. Free GSH (200 mg/kg) and niosomal GSH (14 mg/kg) were effective in reducing hepatotoxicity and hematotoxicity in cats intoxicated with a dose of 150 mg/kg APAP. We conclude that both types of treatments can protect the liver and haemoglobin against oxidative stress in APAP intoxicated cats. Furthermore, our results showed that treatment with niosomal GSH represents an effective therapeutic approach for APAP poisoning.

Key words: Acetaminophen toxicity, Cats, Glutathione, Niosomes.


 
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How to Cite this Article
Pubmed Style

L.A. Denzoin Vulcano,, O. Confalonieri, R. Franci, M.O. Tapia and A.L. Soraci. Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats. Open Vet J. 2013; 3(1): 56-63. doi:10.5455/OVJ.2013.v3.i1.p56


Web Style

L.A. Denzoin Vulcano,, O. Confalonieri, R. Franci, M.O. Tapia and A.L. Soraci. Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats. https://www.openveterinaryjournal.com/?mno=302656876 [Access: February 14, 2024]. doi:10.5455/OVJ.2013.v3.i1.p56


AMA (American Medical Association) Style

L.A. Denzoin Vulcano,, O. Confalonieri, R. Franci, M.O. Tapia and A.L. Soraci. Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats. Open Vet J. 2013; 3(1): 56-63. doi:10.5455/OVJ.2013.v3.i1.p56



Vancouver/ICMJE Style

L.A. Denzoin Vulcano,, O. Confalonieri, R. Franci, M.O. Tapia and A.L. Soraci. Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats. Open Vet J. (2013), [cited February 14, 2024]; 3(1): 56-63. doi:10.5455/OVJ.2013.v3.i1.p56



Harvard Style

L.A. Denzoin Vulcano,, O. Confalonieri, R. Franci, M.O. Tapia and A.L. Soraci (2013) Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats. Open Vet J, 3 (1), 56-63. doi:10.5455/OVJ.2013.v3.i1.p56



Turabian Style

L.A. Denzoin Vulcano,, O. Confalonieri, R. Franci, M.O. Tapia and A.L. Soraci. 2013. Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats. Open Veterinary Journal, 3 (1), 56-63. doi:10.5455/OVJ.2013.v3.i1.p56



Chicago Style

L.A. Denzoin Vulcano,, O. Confalonieri, R. Franci, M.O. Tapia and A.L. Soraci. "Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats." Open Veterinary Journal 3 (2013), 56-63. doi:10.5455/OVJ.2013.v3.i1.p56



MLA (The Modern Language Association) Style

L.A. Denzoin Vulcano,, O. Confalonieri, R. Franci, M.O. Tapia and A.L. Soraci. "Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats." Open Veterinary Journal 3.1 (2013), 56-63. Print. doi:10.5455/OVJ.2013.v3.i1.p56



APA (American Psychological Association) Style

L.A. Denzoin Vulcano,, O. Confalonieri, R. Franci, M.O. Tapia and A.L. Soraci (2013) Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats. Open Veterinary Journal, 3 (1), 56-63. doi:10.5455/OVJ.2013.v3.i1.p56