E-ISSN 2218-6050 | ISSN 2226-4485
 
2025, Vol: 15, Issue: 4
15 / 4Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

OVJ Manuscript Submissio Form

-


Toxic effects of glibenclamide in fetuses of normoglycemic rats: an alternative therapy for gestational diabetes mellitus

L. Aguillar-gomes1, C.m. Lopes2, D.s. Barbieri2, T. Rocha1, * And P. Randazzo-moura2.


Cited By:6

Abstract
Gestational diabetes mellitus (GDM) is defined as glucose intolerance first diagnosed during the second or third trimester of pregnancy. The treatment aims at glycemic control through changes in the patient's diet with or without exercise, but some patients need insulin therapy. An alternative would be to use oral hypoglycemic agents such as glibenclamide (GLIB). The present study aims to analyze the toxic effects of GLIB in fetuses of pregnant rats which received 5 or 20mg/kg doses of GLIB. Glycemic dosage reveals no significant difference between control (deionized water) and treated groups, showing that these concentrations of GLIB were not effective to cause hypoglycemia in rats. The vitality of the fetuses in all groups was 100%. GLIB administration promoted increase in weight and significant changes in measures of external morphological parameters of treated fetuses. Histological analysis revealed that liver lobes, lobules and central lobular veins were well defined for all treatments. However, GLIB animals presented a light brownish precipitate into the center-lobular veins and in the liver parenchyma among the hepatocytes. These results indicated a possible passage of the drug through the blood-placental membrane, without serious changes that impair the development of neither bone tissue, nor the liver of these animals.

Key words: Gestational diabetes mellitus, Glibenclamide, Toxicity.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by L. Aguillar-Gomes1
Articles by C.M. Lopes2
Articles by D.S. Barbieri2
Articles by T. Rocha1
Articles by * and P. Randazzo-Moura2
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Aguillar-gomes L, Lopes C, Barbieri D, Rocha T, Randazzo-moura AP. Toxic effects of glibenclamide in fetuses of normoglycemic rats: an alternative therapy for gestational diabetes mellitus. Open Vet J. 2014; 4(1): 59-64. doi:10.5455/OVJ.2014.v4.i1.p59

Web Style

Aguillar-gomes L, Lopes C, Barbieri D, Rocha T, Randazzo-moura AP. Toxic effects of glibenclamide in fetuses of normoglycemic rats: an alternative therapy for gestational diabetes mellitus. https://www.openveterinaryjournal.com/?mno=302656850 [Access: May 08, 2025]. doi:10.5455/OVJ.2014.v4.i1.p59

AMA (American Medical Association) Style

Aguillar-gomes L, Lopes C, Barbieri D, Rocha T, Randazzo-moura AP. Toxic effects of glibenclamide in fetuses of normoglycemic rats: an alternative therapy for gestational diabetes mellitus. Open Vet J. 2014; 4(1): 59-64. doi:10.5455/OVJ.2014.v4.i1.p59


Vancouver/ICMJE Style

Aguillar-gomes L, Lopes C, Barbieri D, Rocha T, Randazzo-moura AP. Toxic effects of glibenclamide in fetuses of normoglycemic rats: an alternative therapy for gestational diabetes mellitus. Open Vet J. (2014), [cited May 08, 2025]; 4(1): 59-64. doi:10.5455/OVJ.2014.v4.i1.p59


Harvard Style

Aguillar-gomes, L., Lopes, . C., Barbieri, . D., Rocha, . T. & Randazzo-moura, . A. P. (2014) Toxic effects of glibenclamide in fetuses of normoglycemic rats: an alternative therapy for gestational diabetes mellitus. Open Vet J, 4 (1), 59-64. doi:10.5455/OVJ.2014.v4.i1.p59


Turabian Style

Aguillar-gomes, L., C.m. Lopes, D.s. Barbieri, T. Rocha, and And P. Randazzo-moura. 2014. Toxic effects of glibenclamide in fetuses of normoglycemic rats: an alternative therapy for gestational diabetes mellitus. Open Veterinary Journal, 4 (1), 59-64. doi:10.5455/OVJ.2014.v4.i1.p59


Chicago Style

Aguillar-gomes, L., C.m. Lopes, D.s. Barbieri, T. Rocha, and And P. Randazzo-moura. "Toxic effects of glibenclamide in fetuses of normoglycemic rats: an alternative therapy for gestational diabetes mellitus." Open Veterinary Journal 4 (2014), 59-64. doi:10.5455/OVJ.2014.v4.i1.p59


MLA (The Modern Language Association) Style

Aguillar-gomes, L., C.m. Lopes, D.s. Barbieri, T. Rocha, and And P. Randazzo-moura. "Toxic effects of glibenclamide in fetuses of normoglycemic rats: an alternative therapy for gestational diabetes mellitus." Open Veterinary Journal 4.1 (2014), 59-64. Print. doi:10.5455/OVJ.2014.v4.i1.p59


APA (American Psychological Association) Style

Aguillar-gomes, L., Lopes, . C., Barbieri, . D., Rocha, . T. & Randazzo-moura, . A. P. (2014) Toxic effects of glibenclamide in fetuses of normoglycemic rats: an alternative therapy for gestational diabetes mellitus. Open Veterinary Journal, 4 (1), 59-64. doi:10.5455/OVJ.2014.v4.i1.p59


Author LoginReviewer LoginAbout PublisherPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyTerms of UseLicense InformationCopyright Information

About Open Veterinary Journal

Open Veterinary Journal provides a fast track coupled with high quality peer review process for original research articles, review articles, short communi ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes: Owner, Founder and Editor-in-Chief

Open Veterinary Journal


Faculty of Veterinary Medicine, University of Tripoli

P.O. Box 13662, Tripoli, Libya

and


Eldaghayes Publisher

www.eldaghayes.com 

Email: ibrahim.eldaghayes@vetmed.edu.ly