E-ISSN 2218-6050 | ISSN 2226-4485
 
2025, Vol: 15, Issue: 2
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Case Report


A novel encephalopathy in a thiamine-deficient dog resembling human Wernicke’s disease with atypical MRI pattern

Floriana Gernone, Mario Ricciardi.


Cited By:1

Abstract
Thiamine is a water-soluble vitamin, which participates in several vital metabolic pathways involved in energy metabolism and neurotransmitter synthesis of mammals. In companion animals thiamine deficiency is classically associated with signs of diffuse encephalopathy and lesions on brainstem nuclei and mesencephalic colliculi evident on magnetic resonance imaging. This paper describes a novel clinical presentation in a thiamine-deficient dog showing multifocal, central and peripheral nervous and cardiovascular system alterations. Brain MRI showed bilateral caudate nuclei damage, with necrotic-malacic evolution, similar to the atypical MRI pattern found in Wernicke’s encephalopathy in humans. Detection of bilateral symmetrical lesions of the caudate nuclei in dogs should prompt consideration of a thiamine deficiency among the differential diagnoses.

Key words: Key words: thiamine deficiency, dog, Wernicke’s encephalopathy, MRI, caudate nuclei.


 
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How to Cite this Article
Pubmed Style

Gernone F, Ricciardi M. A novel encephalopathy in a thiamine-deficient dog resembling human Wernicke’s disease with atypical MRI pattern. Open Vet J. 2017; 7(4): 313-318. doi:10.4314/ovj.v7i4.4

Web Style

Gernone F, Ricciardi M. A novel encephalopathy in a thiamine-deficient dog resembling human Wernicke’s disease with atypical MRI pattern. https://www.openveterinaryjournal.com/?mno=270289 [Access: March 19, 2025]. doi:10.4314/ovj.v7i4.4

AMA (American Medical Association) Style

Gernone F, Ricciardi M. A novel encephalopathy in a thiamine-deficient dog resembling human Wernicke’s disease with atypical MRI pattern. Open Vet J. 2017; 7(4): 313-318. doi:10.4314/ovj.v7i4.4


Vancouver/ICMJE Style

Gernone F, Ricciardi M. A novel encephalopathy in a thiamine-deficient dog resembling human Wernicke’s disease with atypical MRI pattern. Open Vet J. (2017), [cited March 19, 2025]; 7(4): 313-318. doi:10.4314/ovj.v7i4.4


Harvard Style

Gernone, F. & Ricciardi, . M. (2017) A novel encephalopathy in a thiamine-deficient dog resembling human Wernicke’s disease with atypical MRI pattern. Open Vet J, 7 (4), 313-318. doi:10.4314/ovj.v7i4.4


Turabian Style

Gernone, Floriana, and Mario Ricciardi. 2017. A novel encephalopathy in a thiamine-deficient dog resembling human Wernicke’s disease with atypical MRI pattern. Open Veterinary Journal, 7 (4), 313-318. doi:10.4314/ovj.v7i4.4


Chicago Style

Gernone, Floriana, and Mario Ricciardi. "A novel encephalopathy in a thiamine-deficient dog resembling human Wernicke’s disease with atypical MRI pattern." Open Veterinary Journal 7 (2017), 313-318. doi:10.4314/ovj.v7i4.4


MLA (The Modern Language Association) Style

Gernone, Floriana, and Mario Ricciardi. "A novel encephalopathy in a thiamine-deficient dog resembling human Wernicke’s disease with atypical MRI pattern." Open Veterinary Journal 7.4 (2017), 313-318. Print. doi:10.4314/ovj.v7i4.4


APA (American Psychological Association) Style

Gernone, F. & Ricciardi, . M. (2017) A novel encephalopathy in a thiamine-deficient dog resembling human Wernicke’s disease with atypical MRI pattern. Open Veterinary Journal, 7 (4), 313-318. doi:10.4314/ovj.v7i4.4


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