E-ISSN 2218-6050 | ISSN 2226-4485
 
2024, Vol: 14, Issue: 11
14 / 11Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

OVJ Manuscript Submission Form

Original Article


Comparison between fish and linseed oils administered orally for the treatment of experimentally induced keratoconjunctivitis sicca in rabbits

Danielle Alves Silva, Gisele Alborgetti Nai, Rogério Giuffrida, Rafael Cabral Barbero, Jacqueline Marcussi Pereira Kuhn, Andressa Carolina da Silva, Ricardo Henrique Zakir Pereira, Maria Fernanda Abbade, Luis Felipe da Costa Zulim, Carolina Silva Guimarães, Silvia Franco Andrade.


Cited By:9

Abstract
The objective of this study was to compare the efficacy of two sources of omega 3 and 6, fish oil (FO) and linseed oil (LO), orally administered, alone or in combination, for treating experimentally induced keratoconjunctivitis sicca (KCS) in rabbits. Twenty-eight New Zealand rabbits were used in this study. Seven animals were allocated to the C group (negative control), and KCS was induced in 21 animals by topically applying 1% atropine sulfate drops for 7 days. Treatment with atropine was maintained throughout the study period (12 weeks). The rabbits were divided into 3 treatment groups containing 7 animals each: FO group, LO group and FLO group (FO and LO). The animals were evaluated using the Schirmer Tear Test I (STT I), Rose Bengal Test (RBT), fluorescein test (FT), tear film break-up time (TBUT), and conjunctival and histopathological analysis. There was a significant increase in STT I and TBUT values in treatment groups, but the increase occurred earlier in the FO group. The results of the RBT and FT were similar among treatment groups, except FT, in the FLO group, negative staining was only in 12 weeks. There was a significant decrease in the number of goblet cells in the FLO group compared with the other groups. The results demonstrated that orally administered of FO and LO improved the clinical signs of KCS. However, improvement occurred earlier in the FO group. Using oils in combination did not provide additional benefits. These results contribute to the future development of new oral formulations as adjuvant therapies for KCS.

Key words: Fish oil, Keratoconjunctivitis sicca, Linseed oil, Oral, Rabbits


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Danielle Alves Silva
Articles by Gisele Alborgetti Nai
Articles by Rogério Giuffrida
Articles by Rafael Cabral Barbero
Articles by Jacqueline Marcussi Pereira Kuhn
Articles by Andressa Carolina da Silva
Articles by Ricardo Henrique Zakir Pereira
Articles by Maria Fernanda Abbade
Articles by Luis Felipe da Costa Zulim
Articles by Carolina Silva Guimarães
Articles by Silvia Franco Andrade
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Danielle Alves Silva, Gisele Alborgetti Nai, Rogério Giuffrida, Rafael Cabral Barbero, Jacqueline Marcussi Pereira Kuhn, Andressa Carolina da Silva, Ricardo Henrique Zakir Pereira, Maria Fernanda Abbade, Luis Felipe da Costa Zulim, Carolina Silva Guimarães, Silvia Franco Andrade. Comparison between fish and linseed oils administered orally for the treatment of experimentally induced keratoconjunctivitis sicca in rabbits. Open Vet J. 2017; 7(3): 277-285. doi:10.4314/ovj.v7i3.13

Web Style

Danielle Alves Silva, Gisele Alborgetti Nai, Rogério Giuffrida, Rafael Cabral Barbero, Jacqueline Marcussi Pereira Kuhn, Andressa Carolina da Silva, Ricardo Henrique Zakir Pereira, Maria Fernanda Abbade, Luis Felipe da Costa Zulim, Carolina Silva Guimarães, Silvia Franco Andrade. Comparison between fish and linseed oils administered orally for the treatment of experimentally induced keratoconjunctivitis sicca in rabbits. https://www.openveterinaryjournal.com/?mno=264517 [Access: December 07, 2024]. doi:10.4314/ovj.v7i3.13

AMA (American Medical Association) Style

Danielle Alves Silva, Gisele Alborgetti Nai, Rogério Giuffrida, Rafael Cabral Barbero, Jacqueline Marcussi Pereira Kuhn, Andressa Carolina da Silva, Ricardo Henrique Zakir Pereira, Maria Fernanda Abbade, Luis Felipe da Costa Zulim, Carolina Silva Guimarães, Silvia Franco Andrade. Comparison between fish and linseed oils administered orally for the treatment of experimentally induced keratoconjunctivitis sicca in rabbits. Open Vet J. 2017; 7(3): 277-285. doi:10.4314/ovj.v7i3.13


Vancouver/ICMJE Style

Danielle Alves Silva, Gisele Alborgetti Nai, Rogério Giuffrida, Rafael Cabral Barbero, Jacqueline Marcussi Pereira Kuhn, Andressa Carolina da Silva, Ricardo Henrique Zakir Pereira, Maria Fernanda Abbade, Luis Felipe da Costa Zulim, Carolina Silva Guimarães, Silvia Franco Andrade. Comparison between fish and linseed oils administered orally for the treatment of experimentally induced keratoconjunctivitis sicca in rabbits. Open Vet J. (2017), [cited December 07, 2024]; 7(3): 277-285. doi:10.4314/ovj.v7i3.13


Harvard Style

Danielle Alves Silva, Gisele Alborgetti Nai, Rogério Giuffrida, Rafael Cabral Barbero, Jacqueline Marcussi Pereira Kuhn, Andressa Carolina da Silva, Ricardo Henrique Zakir Pereira, Maria Fernanda Abbade, Luis Felipe da Costa Zulim, Carolina Silva Guimarães, Silvia Franco Andrade (2017) Comparison between fish and linseed oils administered orally for the treatment of experimentally induced keratoconjunctivitis sicca in rabbits. Open Vet J, 7 (3), 277-285. doi:10.4314/ovj.v7i3.13


Turabian Style

Danielle Alves Silva, Gisele Alborgetti Nai, Rogério Giuffrida, Rafael Cabral Barbero, Jacqueline Marcussi Pereira Kuhn, Andressa Carolina da Silva, Ricardo Henrique Zakir Pereira, Maria Fernanda Abbade, Luis Felipe da Costa Zulim, Carolina Silva Guimarães, Silvia Franco Andrade. 2017. Comparison between fish and linseed oils administered orally for the treatment of experimentally induced keratoconjunctivitis sicca in rabbits. Open Veterinary Journal, 7 (3), 277-285. doi:10.4314/ovj.v7i3.13


Chicago Style

Danielle Alves Silva, Gisele Alborgetti Nai, Rogério Giuffrida, Rafael Cabral Barbero, Jacqueline Marcussi Pereira Kuhn, Andressa Carolina da Silva, Ricardo Henrique Zakir Pereira, Maria Fernanda Abbade, Luis Felipe da Costa Zulim, Carolina Silva Guimarães, Silvia Franco Andrade. "Comparison between fish and linseed oils administered orally for the treatment of experimentally induced keratoconjunctivitis sicca in rabbits." Open Veterinary Journal 7 (2017), 277-285. doi:10.4314/ovj.v7i3.13


MLA (The Modern Language Association) Style

Danielle Alves Silva, Gisele Alborgetti Nai, Rogério Giuffrida, Rafael Cabral Barbero, Jacqueline Marcussi Pereira Kuhn, Andressa Carolina da Silva, Ricardo Henrique Zakir Pereira, Maria Fernanda Abbade, Luis Felipe da Costa Zulim, Carolina Silva Guimarães, Silvia Franco Andrade. "Comparison between fish and linseed oils administered orally for the treatment of experimentally induced keratoconjunctivitis sicca in rabbits." Open Veterinary Journal 7.3 (2017), 277-285. Print. doi:10.4314/ovj.v7i3.13


APA (American Psychological Association) Style

Danielle Alves Silva, Gisele Alborgetti Nai, Rogério Giuffrida, Rafael Cabral Barbero, Jacqueline Marcussi Pereira Kuhn, Andressa Carolina da Silva, Ricardo Henrique Zakir Pereira, Maria Fernanda Abbade, Luis Felipe da Costa Zulim, Carolina Silva Guimarães, Silvia Franco Andrade (2017) Comparison between fish and linseed oils administered orally for the treatment of experimentally induced keratoconjunctivitis sicca in rabbits. Open Veterinary Journal, 7 (3), 277-285. doi:10.4314/ovj.v7i3.13


Author LoginReviewer LoginAbout PublisherPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyTerms of UseLicense Information

About Open Veterinary Journal

Open Veterinary Journal provides a fast track coupled with high quality peer review process for original research articles, review articles, short communi ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes: Owner, Founder and Editor-in-Chief

Open Veterinary Journal


Faculty of Veterinary Medicine, University of Tripoli

P.O. Box 13662, Tripoli, Libya

and


Eldaghayes Publisher

www.eldagpublisher.com 

Email: ibrahim.eldaghayes@vetmed.edu.ly