Abstract
Background:
The most widespread conditions that affected on primarily male population is Benign hyperplasia of the prostate BPH. Flax seeds has been reported to antiproliferation properties and exhibit antitumor.
Aim:
We assessed the impact of Flax seeds ethanolic excerpt on BPH within testosterone propionate induced model of rats.
Methods:
A pre-3-week daily injection of testosterone propionate (3 mg/kg BW) was used to induce BPH. Twenty male rats (200-240 gm) were randomly divided to 4 equal groups (n=5) negative Group under control was given PBS orally, corn oil S/C, BPH induced rats received 3mg/kg BW TP for 3 weeks, extract group received 50 mg/Kg extract twice daily for 2 weeks Finasteride group received standard drug 10 mg/Kg BW for 2 weeks. When the course of treatment is over, rats were sacrificed and the blood was collected and separated, the prostate of the rats were harvested for histological examination.
Results:
The results showed that flax seeds ethanolic extract could significantly (P<0.05) reduce the prostate gland weight, prostate index, serum level of PAS, testosterone,5-a reductase enzyme in BPH induced rats and improved the tissue morphology of the prostate.
Conclusion:
Based on our results, extract suggested that have promising role for the treatment of benign hyperplasia of the prostate.

Key words: Finasteride, Flax seeds, Prostatic hyperplasia, Testosterone, Tissue morphology