E-ISSN 2218-6050 | ISSN 2226-4485
 

Research Article


Exploring blood pressure dynamics and oxidative stress markers in an animal model of polycystic ovary syndrome

Yudit Oktanella, Hana Ismiawati, Hafizh Zakaria, Handayu Untari.


Abstract
Background:
Polycystic Ovary Syndrome (PCOS) is a hormonal disorder characterized by elevated androgen levels, heightened insulin secretion, and dysregulation of Luteinizing Hormone and Follicle Stimulating Hormone. This disorder results in metabolic disruptions, while the irregular estrous cycles associated with PCOS impact cellular functions like growth, movement, and alterations in cell adhesion within the tissue matrix.
Aim:
This study aims to identify the blood tension, serum malondialdehyde (MDA) levels and serum MMP-1 in rat model of PCOS. The study was conducted using female Wistar rats aged 6 months weighing between 130-180 grams.
Methods:
The rats were divided into three treatment groups: negative control, induction of Testosterone Propionate (TP) at a dose of 100 mg/kg BW IP for 12 days, and induction of Estradiol Valerate (EV) at a dose of 2 mg/kg BW IP for 2 days. Data were analyzed quantitatively using one-way Analysis of Variance (ANOVA) followed by Posthoc Test using the Least Significant Difference with a confidence level of 95%.
Results:
The research results indicate that the average blood pressure of TP Group and EV Group did not differ significantly from the negative control (p>0.05). Serum MDA levels were significantly different in TP Group compared to the negative control (p<0.05). On the other hand, MMP-1 levels showed no significant difference (p>0.05) among all the treatment groups.
Conclusion:
The findings of this study suggest that testosterone propionate induction in a rat model of PCOS can potentially contribute to oxidative stress and lipid peroxidation, but does not significantly affect blood pressure or serum MMP-1 levels.

Key words: PCOS, Blood-pressure, Animal models, MMP-1, Malondialdehyde


 
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How to Cite this Article
Pubmed Style

Oktanella Y, Ismiawati H, Zakaria H, Untari H. Exploring blood pressure dynamics and oxidative stress markers in an animal model of polycystic ovary syndrome. Open Vet J. 2024; 14(8): 1858-1865. doi:10.5455/OVJ.2024.v14.i8.14


Web Style

Oktanella Y, Ismiawati H, Zakaria H, Untari H. Exploring blood pressure dynamics and oxidative stress markers in an animal model of polycystic ovary syndrome. https://www.openveterinaryjournal.com/?mno=197884 [Access: October 03, 2024]. doi:10.5455/OVJ.2024.v14.i8.14


AMA (American Medical Association) Style

Oktanella Y, Ismiawati H, Zakaria H, Untari H. Exploring blood pressure dynamics and oxidative stress markers in an animal model of polycystic ovary syndrome. Open Vet J. 2024; 14(8): 1858-1865. doi:10.5455/OVJ.2024.v14.i8.14



Vancouver/ICMJE Style

Oktanella Y, Ismiawati H, Zakaria H, Untari H. Exploring blood pressure dynamics and oxidative stress markers in an animal model of polycystic ovary syndrome. Open Vet J. (2024), [cited October 03, 2024]; 14(8): 1858-1865. doi:10.5455/OVJ.2024.v14.i8.14



Harvard Style

Oktanella, Y., Ismiawati, . H., Zakaria, . H. & Untari, . H. (2024) Exploring blood pressure dynamics and oxidative stress markers in an animal model of polycystic ovary syndrome. Open Vet J, 14 (8), 1858-1865. doi:10.5455/OVJ.2024.v14.i8.14



Turabian Style

Oktanella, Yudit, Hana Ismiawati, Hafizh Zakaria, and Handayu Untari. 2024. Exploring blood pressure dynamics and oxidative stress markers in an animal model of polycystic ovary syndrome. Open Veterinary Journal, 14 (8), 1858-1865. doi:10.5455/OVJ.2024.v14.i8.14



Chicago Style

Oktanella, Yudit, Hana Ismiawati, Hafizh Zakaria, and Handayu Untari. "Exploring blood pressure dynamics and oxidative stress markers in an animal model of polycystic ovary syndrome." Open Veterinary Journal 14 (2024), 1858-1865. doi:10.5455/OVJ.2024.v14.i8.14



MLA (The Modern Language Association) Style

Oktanella, Yudit, Hana Ismiawati, Hafizh Zakaria, and Handayu Untari. "Exploring blood pressure dynamics and oxidative stress markers in an animal model of polycystic ovary syndrome." Open Veterinary Journal 14.8 (2024), 1858-1865. Print. doi:10.5455/OVJ.2024.v14.i8.14



APA (American Psychological Association) Style

Oktanella, Y., Ismiawati, . H., Zakaria, . H. & Untari, . H. (2024) Exploring blood pressure dynamics and oxidative stress markers in an animal model of polycystic ovary syndrome. Open Veterinary Journal, 14 (8), 1858-1865. doi:10.5455/OVJ.2024.v14.i8.14