E-ISSN 2218-6050 | ISSN 2226-4485
 
2024, Vol: 14, Issue: 3
14 / 3Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

OVJ Manuscript Submission Form

Short Communication


The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery

Shelby L Mancini, Peter Early, Karen Munana, Natasha Olby, Christopher Mariani, Bethany Pastina.


Cited By:1

Abstract
Background: Cytarabine (CA) is used to treat dogs with meningoencephalomyelitis of unknown etiology (MUE) by subcutaneous (SC) or intravenous (IV) administration.
Aim: The objective was to investigate transdermal iontophoresis and rectal administration as alternative routes of CA delivery.
Methods: Two client-owned dogs with MUE were studied. The ActivaPatch® IONTOGO™ 12.0 iontophoresis drug delivery system delivered 200 mg/m^2 CA transdermally. Blood samples were collected by sparse sampling technique after initiation of the device. At another visit, 100 mg/m^2 CA was administered rectally. Blood samples were collected by sparse sampling technique after administration. Plasma CA concentrations were measured by high-pressure liquid chromatography (HPLC).
Results: The concentration of plasma CA after transdermal and rectal administration was below the limits of quantification (0.1ug/mL) in all samples suggesting inadequate bioavailability with transdermal and rectal administration.
Conclusion: Transdermal and rectal CA administration are not reasonable alternative routes of delivery.

Key words: dog, meningoencephalitis, cytarabine, bioavailability


 
ARTICLE TOOLS
Abstract
PDF Fulltext
HTML Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Shelby L Mancini
Articles by Peter Early
Articles by Karen Munana
Articles by Natasha Olby
Articles by Christopher Mariani
Articles by Bethany Pastina
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Mancini SL, Early P, Munana K, Olby N, Mariani C, Pastina B, . The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery. Open Vet J. 2021; 11(1): 36-38. doi:10.4314/ovj.v11i1.6

Web Style

Mancini SL, Early P, Munana K, Olby N, Mariani C, Pastina B, . The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery. https://www.openveterinaryjournal.com/?mno=134239 [Access: April 10, 2024]. doi:10.4314/ovj.v11i1.6

AMA (American Medical Association) Style

Mancini SL, Early P, Munana K, Olby N, Mariani C, Pastina B, . The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery. Open Vet J. 2021; 11(1): 36-38. doi:10.4314/ovj.v11i1.6


Vancouver/ICMJE Style

Mancini SL, Early P, Munana K, Olby N, Mariani C, Pastina B, . The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery. Open Vet J. (2021), [cited April 10, 2024]; 11(1): 36-38. doi:10.4314/ovj.v11i1.6


Harvard Style

Mancini, S. L., Early, P., Munana, K., Olby, N., Mariani, C., Pastina, B. & (2021) The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery. Open Vet J, 11 (1), 36-38. doi:10.4314/ovj.v11i1.6


Turabian Style

Mancini, Shelby L, Peter Early, Karen Munana, Natasha Olby, Christopher Mariani, Bethany Pastina, and . 2021. The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery. Open Veterinary Journal, 11 (1), 36-38. doi:10.4314/ovj.v11i1.6


Chicago Style

Mancini, Shelby L, Peter Early, Karen Munana, Natasha Olby, Christopher Mariani, Bethany Pastina, and . "The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery." Open Veterinary Journal 11 (2021), 36-38. doi:10.4314/ovj.v11i1.6


MLA (The Modern Language Association) Style

Mancini, Shelby L, Peter Early, Karen Munana, Natasha Olby, Christopher Mariani, Bethany Pastina, and . "The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery." Open Veterinary Journal 11.1 (2021), 36-38. Print. doi:10.4314/ovj.v11i1.6


APA (American Psychological Association) Style

Mancini, S. L., Early, P., Munana, K., Olby, N., Mariani, C., Pastina, B. & (2021) The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery. Open Veterinary Journal, 11 (1), 36-38. doi:10.4314/ovj.v11i1.6


Author LoginReviewer LoginAbout PublisherPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyTerms of UseLicense Information

About Open Veterinary Journal

Open Veterinary Journal provides a fast track coupled with high quality peer review process for original research articles, review articles, short communi ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes: Owner, Founder and Editor-in-Chief

Open Veterinary Journal, Faculty of Veterinary Medicine, University of Tripoli

P.O. Box 13662, Tripoli, Libya


Email: ibrahim.eldaghayes@vetmed.edu.ly