E-ISSN 2218-6050 | ISSN 2226-4485
 

Research Article


Pharmacodynamics of single-dose omecamtiv mecarbil administered intravenously in clinically healthy cats

Mio Ishizaka, Huai-hsun Hsu, Yuichi Miyagawa, Naoyuki Takemura.


Abstract
Background:
Omecamtiv mecarbil (OM), a selective cardiac myosin activator, is gaining attention as a potential heart failure treatment because it can enhance cardiac contractility without adverse effects. Concerns were raised about arrhythmias with conventional heart failure treatments in cats. Despite OM’s promise in veterinary medicine, no studies have confirmed its efficacy in cats.

Aim:
This study aimed to investigate the pharmacodynamics of OM in cats.

Methods:
Five clinically healthy cats were used. OM’s efficacy was examined in three doses: 0.1, 0.25, and 1.0 mg/kg. To minimize the effect on heart rates, the cats were under general anesthesia, and baseline measurements were taken after the heart rate and blood pressure had stabilized. OM was administered as a single intravenous injection. Echocardiography was performed 15, 30, 60, 90, and 120 min after administration. Heart rate and blood pressure were measured before each echocardiographic examination.

Results:
The heart rates decreased at all doses; significant reductions were seen at 0.25 and 1.0 mg/kg. All doses enhanced cardiac contractility, showing a dose-dependent effect. Blood pressure remained unchanged.

Conclusion:
OM enhances cardiac contractility in cats, with 0.25 mg/kg being the optimal dose.

Key words: Omecamtiv mecarbil, Feline, Heart failure, Cardiomyopathy


 
ARTICLE TOOLS
Abstract
PDF Fulltext

About Open Veterinary Journal


Open Veterinary Journal provides a fast track coupled with high quality peer review process for original research articles, review articles, short communi ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information


All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes: Owner, Founder and Editor-in-Chief

Open Veterinary Journal


Faculty of Veterinary MedicineUniversity of Tripoli

P.O. Box 13662, Tripoli, Libya

and


Eldaghayes Publisher

www.eldaghayes.com 

Email: ibrahim.eldaghayes@vetmed.edu.ly