Abstract
Background:
Natural materials are frequently good options for drug development, regardless of their source. It has been demonstrated that curcumin boosts antioxidant capacity and guards against diabetic disorders.

Aim:
The current study aimed to evaluate the possible anti-inflammatory and anti-diabetic effects of curcumin-NPs (Cur-NPs) in streptozotocin (STZ)-induced diabetic rats.

Methods:
Four groups of rats were randomly selected; (1) standard control group, (2) Cur-NPs group was given the regular food of rats along with 5 mg/kg of Cur-NPs daily, (3) Diabetic rats in the STZ group served as the positive control, and (4) Included in the STZ~Cur-NPs group were diabetic rats receiving Cur-NPs (5 mg/kg/day).

Results:
After receiving Cur-NPs treatment for six weeks, the levels of glucose, TNF-α, IL1β, IL-4, IL-6, IL-10, MDA, and NO in the diabetic animals were significantly reduced. Simultaneously, the levels of insulin, CAT, GPx, GSH, and SOD were significantly increased, approaching the levels of the corresponding healthy animals. Similarly, insulin secretion increased in the islet β-cells as shown by immunohistochemical analysis, indicating improved glycaemic control and eventual glucose commitment to glycolysis; its processes for scavenging free radicals and acting as an antioxidant may explain this behavior.

Conclusion:
As a result, our findings aid in the potential characterization and creation of novel therapeutic agents that prevent diabetes.

Key words: Immunohistochemical, Curcumin-NPs, Diabetes, STZ, Anti-inflammatory