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Research Article


Ameliorative effect of Odontonema cuspidatum extract against testicular damage induced by sodium nitrite in rats

Nesma H. Elsawy, Samir A. Elshazly, Azza Elkattawy, Nasr E. Nasr, Essam A. Almadaly, Mohamed S. Refaey, Khaled A. Kahillo, Mona Assas, Walied Abdo, Aml S. Hashem, Tarek K. Abouzaid, Doaa A. Dourgham.


Abstract
Background:
Sodium nitrite (NaNO2) is a chemical substance used to enhance taste, add color, and keep food products fit for consumption for a longer time. NaNO2 gives rise to a negative adverse effect on male reproductive function. Odontonema cuspidatum (OC) is a natural plant that possesses antioxidant capacity.
Aim:
Our research evaluates the potential beneficial effect of Odontonema cuspidatum extract on the harmful effects caused by NaNO2 on the testicular tissue and sperm characteristics of male rats.
Methods:
Four groups with a total of forty rats: the control, the NaNO2-received group, the OC-administered group, and the fourth group received both NaNO2 and OC. All groups were administered daily for two months. Sperm characteristics, testicular antioxidant status and histopathological changes were evaluated.
Results:
Coadministration of NaNO2 and OC, in comparison with NaNO2 alone, contributed to a notable enhancement in acrosomal integrity, decreasing sperm abnormalities and restoring serum testosterone levels. Moreover, such coadministration reduced the oxidative stress marker, MDA, and increased SOD in testicular tissue, lowering TNF-α gene expression, and increasing the expression of P450scc and StAR genes. Additionally, the NaNO2 and OC combination decreased the testicular histopathological changes and the Caspase-3 and PCNA immunoexpression in seminiferous tubules compared with the NaNO2 group.
Conclusion:
The extract of Odontonema cuspidatum exhibited the ability to decrease oxidative stress and ameliorate the detrimental effects caused by NaNO2.

Key words: NaNO2, Odontonema cuspidatum, Food additives, Testicular damage


 
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How to Cite this Article
Pubmed Style

Elsawy NH, Elshazly SA, Elkattawy A, Nasr NE, Almadaly EA, Refaey MS, Kahillo KA, Assas M, Abdo W, Hashem AS, Abouzaid TK, Dourgham DA, . Ameliorative effect of Odontonema cuspidatum extract against testicular damage induced by sodium nitrite in rats. Open Vet J. 2024; 14((1) (Zagazig Veterinary Conference)): 304-315. doi:10.5455/OVJ.2024.v14.i1.27


Web Style

Elsawy NH, Elshazly SA, Elkattawy A, Nasr NE, Almadaly EA, Refaey MS, Kahillo KA, Assas M, Abdo W, Hashem AS, Abouzaid TK, Dourgham DA, . Ameliorative effect of Odontonema cuspidatum extract against testicular damage induced by sodium nitrite in rats. https://www.openveterinaryjournal.com/?mno=177407 [Access: April 09, 2024]. doi:10.5455/OVJ.2024.v14.i1.27


AMA (American Medical Association) Style

Elsawy NH, Elshazly SA, Elkattawy A, Nasr NE, Almadaly EA, Refaey MS, Kahillo KA, Assas M, Abdo W, Hashem AS, Abouzaid TK, Dourgham DA, . Ameliorative effect of Odontonema cuspidatum extract against testicular damage induced by sodium nitrite in rats. Open Vet J. 2024; 14((1) (Zagazig Veterinary Conference)): 304-315. doi:10.5455/OVJ.2024.v14.i1.27



Vancouver/ICMJE Style

Elsawy NH, Elshazly SA, Elkattawy A, Nasr NE, Almadaly EA, Refaey MS, Kahillo KA, Assas M, Abdo W, Hashem AS, Abouzaid TK, Dourgham DA, . Ameliorative effect of Odontonema cuspidatum extract against testicular damage induced by sodium nitrite in rats. Open Vet J. (2024), [cited April 09, 2024]; 14((1) (Zagazig Veterinary Conference)): 304-315. doi:10.5455/OVJ.2024.v14.i1.27



Harvard Style

Elsawy, N. H., Elshazly, S. A., Elkattawy, A., Nasr, N. E., Almadaly, E. A., Refaey, M. S., Kahillo, K. A., Assas, M., Abdo, W., Hashem, A. S., Abouzaid, T. K., Dourgham, D. A. & (2024) Ameliorative effect of Odontonema cuspidatum extract against testicular damage induced by sodium nitrite in rats. Open Vet J, 14 ((1) (Zagazig Veterinary Conference)), 304-315. doi:10.5455/OVJ.2024.v14.i1.27



Turabian Style

Elsawy, Nesma H., Samir A. Elshazly, Azza Elkattawy, Nasr E. Nasr, Essam A. Almadaly, Mohamed S. Refaey, Khaled A. Kahillo, Mona Assas, Walied Abdo, Aml S. Hashem, Tarek K. Abouzaid, Doaa A. Dourgham, and . 2024. Ameliorative effect of Odontonema cuspidatum extract against testicular damage induced by sodium nitrite in rats. Open Veterinary Journal, 14 ((1) (Zagazig Veterinary Conference)), 304-315. doi:10.5455/OVJ.2024.v14.i1.27



Chicago Style

Elsawy, Nesma H., Samir A. Elshazly, Azza Elkattawy, Nasr E. Nasr, Essam A. Almadaly, Mohamed S. Refaey, Khaled A. Kahillo, Mona Assas, Walied Abdo, Aml S. Hashem, Tarek K. Abouzaid, Doaa A. Dourgham, and . "Ameliorative effect of Odontonema cuspidatum extract against testicular damage induced by sodium nitrite in rats." Open Veterinary Journal 14 (2024), 304-315. doi:10.5455/OVJ.2024.v14.i1.27



MLA (The Modern Language Association) Style

Elsawy, Nesma H., Samir A. Elshazly, Azza Elkattawy, Nasr E. Nasr, Essam A. Almadaly, Mohamed S. Refaey, Khaled A. Kahillo, Mona Assas, Walied Abdo, Aml S. Hashem, Tarek K. Abouzaid, Doaa A. Dourgham, and . "Ameliorative effect of Odontonema cuspidatum extract against testicular damage induced by sodium nitrite in rats." Open Veterinary Journal 14.(1) (Zagazig Veterinary Conference) (2024), 304-315. Print. doi:10.5455/OVJ.2024.v14.i1.27



APA (American Psychological Association) Style

Elsawy, N. H., Elshazly, S. A., Elkattawy, A., Nasr, N. E., Almadaly, E. A., Refaey, M. S., Kahillo, K. A., Assas, M., Abdo, W., Hashem, A. S., Abouzaid, T. K., Dourgham, D. A. & (2024) Ameliorative effect of Odontonema cuspidatum extract against testicular damage induced by sodium nitrite in rats. Open Veterinary Journal, 14 ((1) (Zagazig Veterinary Conference)), 304-315. doi:10.5455/OVJ.2024.v14.i1.27