Open Veterinary Journal

Open Veterinary Journal

Peer-Reviewed Journal 
ISSN 2218-6050 (Online), ISSN 2226-4485 (Print) 

"Short Communication"

The bioavailability of cytarabine in dogs with meningoencephalitis of unknown etiology through iontophoresis and rectal delivery


Shelby L. Mancini(1), Peter J. Early(1*), Bethany O. Pastina(2), Natasha J. Olby(1), Christopher L. Mariani(1) and Karen R. Munana(1)


1- NC State University Veterinary Hospital, 1052 William Moore Drive, Raleigh, NC, 27607, USA

2- Veterinary Medical Center of Long Island, 75 Sunrise Highway, West Islip, NY, 11795-2033, USA

Abstract

Background: Cytarabine (CA) is used to treat dogs with meningoencephalitis of unknown etiology (MUE) by subcutaneous (SC) or intravenous (IV) administration.

Aim: The objective was to investigate transdermal iontophoresis and rectal administration as alternative routes of CA delivery.

Methods: Two client-owned dogs with MUE were studied. The ActivaPatch® IONTOGO™ 12.0 iontophoresis drug delivery system delivered 200 mg/m^2 CA transdermally. Blood samples were collected by sparse sampling technique after initiation of the device. At another visit, 100 mg/m^2 CA was administered rectally. Blood samples were collected by sparse sampling technique after administration. Plasma CA concentrations were measured by high-pressure liquid chromatography (HPLC).

Results: The concentration of plasma CA after transdermal and rectal administration was below the limits of quantification (0.1ug/mL) in all samples suggesting inadequate bioavailability with transdermal and rectal administration.

Conclusion: Transdermal and rectal CA administration are not reasonable alternative routes of delivery.

Keywords: Dog, Meningoencephalitis, Cytarabine, Bioavailability.

Cite this paper:
Mancini, S.L., Early, P.J., Pastina, B.O., Olby, N.J., Mariani, C.L. and Munana, K.R. 2021. The bioavailability of cytarabine in dogs with meningoencephalitis of unknown etiology through iontophoresis and rectal delivery. Open Vet. J. 11(1), 36-38.