Open Veterinary Journal

Open Veterinary Journal

Peer-Reviewed Journal 
ISSN 2218-6050 (Online), ISSN 2226-4485 (Print) 

"Original Research"

Canine cognitive dysfunction patients have reduced total hippocampal volume compared with aging control dogs: A comparative magnetic resonance imaging study


Curtis Wells Dewey(1,2,3*), Mark Rishniw(1), Philippa J. Johnson(1), Simon Platt(4), Kelsey Robinson(4), Joseph Sackman(2) and Marissa O’Donnell(2)


1- Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA

2- Department of Surgery, Long Island Veterinary Specialists, Plainview, NY, USA

3- Rochester Veterinary Specialists and Emergency Services, College of Veterinary Medicine, University of Georgia, Athens, GA, USA

4- Department of Small Animal Medicine & Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA, USA

Abstract

Background: Hippocampal atrophy is a key pathologic and MRI feature of human Alzheimer’s disease (AD). Hippocampal atrophy has not been documented via MRI in canine cognitive dysfunction (CCD), which is considered the dog model of human AD.

Aim: The purpose of this retrospective comparative volumetric MRI study was to compare total hippocampal volumes between successfully aging (control) dogs and dogs diagnosed with CCD.

Methods: Mimics® software was used to derive total hippocampal volumes and total brain volumes from the MRI studies of 42 aging dogs (> 9 years): 16 dogs diagnosed with CCD and 26 successfully aging controls. Hippocampal volumes were normalized to total brain volume and these values were compared between groups using Mann Whitney U Tests.

Results: Total hippocampal volume normalized to total brain volume was significantly less for CCD patients compared with control dogs (p=0.04).

Conclusion: The results of this study suggest that-similar to human AD-hippocampal atrophy is a pathological feature of CCD. This finding has potential importance for both investigating disease mechanisms related to dementia as well as future hippocampal-targeted therapies.

Keywords: Canine, Cognitive, Dog, Hippocampal, Volume.

Cite this paper:

Dewey, C.W., Rishniw, M., Johnson, P.J., Platt, S., Robinson, K., Sackman, J. and O’Donnell, M. 2020. Canine cognitive dysfunction patients have reduced total hippocampal volume compared with aging control dogs: A comparative magnetic resonance imaging study. Open Vet. J. 10(4), 438-442.