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Review Article


Role of celery (Apium graveolens) in reducing uric acid and cholesterol in experimental animals: A literature review

Dewi Ramdani, Aswin Rafif Khairullah, Hani Plumeriastuti, Mustofa Helmi Effendi, Bima Putra Pratama, Emmanuel Nnabuike Ugbo, Budiastuti Budiastuti, Vitra Nuraini Helmi, Syahputra Wibowo, Riza Zainuddin Ahmad, Ikechukwu Benjamin Moses, Muhammad ‘ahdi Kurniawan, Saifur Rehman, Ilma Fauziah Ma’ruf, Fadhila Utari.


Abstract
Celery (Apium graveolens) is a herb containing various bioactive compounds, including flavonoids, phthalides, and saponins, known to have biological activity in the regulation of purine and lipid metabolism. Hyperuricemia and dyslipidemia are common metabolic disorders in both experimental animals and humans, contributing to organ damage through oxidative stress and inflammatory processes. Therefore, the search for safe and efficacious natural interventions is a crucial concern in the prevention and management of both conditions. This review aims to examine the scientific evidence regarding the role of celery in reducing uric acid and cholesterol levels in experimental animals, while also examining the bioactive mechanisms involved. Several studies have shown that celery extract supplementation consistently reduces plasma uric acid levels through inhibition of xanthine oxidase activity and increased purine elimination. Furthermore, celery has been shown to improve plasma lipid profiles by reducing LDL and triglyceride levels and increasing HDL. The level of effectiveness is influenced by several factors, such as dose, duration of administration, plant part used, type of extract, and species of test animal. Overall, the experimental data indicate that celery acts through a multi-target mechanism to lower uric acid and cholesterol levels, while also providing a protective effect on vital organs by suppressing oxidative stress. These findings strengthen the scientific basis for celery's use as a candidate natural therapeutic agent in the management of metabolic disorders in animal models and provide a foundation for further research into optimal dosage, duration of administration, and underlying molecular mechanisms.

Key words: Celery; Apium graveolens; Uric acid; Cholesterol; Animal studies; Human health.


 
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How to Cite this Article
Pubmed Style

Ramdani D, Khairullah AR, Plumeriastuti H, Effendi MH, Pratama BP, Ugbo EN, Budiastuti B, Helmi VN, Wibowo S, Ahmad RZ, Moses IB, Kurniawan Mâ, Rehman S, Ma'ruf IF, Utari F. Role of celery (Apium graveolens) in reducing uric acid and cholesterol in experimental animals: A literature review. Open Vet. J.. 2026; 16(6): 3861-3878. doi:10.5455/OVJ.2026.v16.i6.56

Web Style

Ramdani D, Khairullah AR, Plumeriastuti H, Effendi MH, Pratama BP, Ugbo EN, Budiastuti B, Helmi VN, Wibowo S, Ahmad RZ, Moses IB, Kurniawan Mâ, Rehman S, Ma'ruf IF, Utari F. Role of celery (Apium graveolens) in reducing uric acid and cholesterol in experimental animals: A literature review. https://www.openveterinaryjournal.com/?mno=308135 [Access: June 19, 2026]. doi:10.5455/OVJ.2026.v16.i6.56

AMA (American Medical Association) Style

Ramdani D, Khairullah AR, Plumeriastuti H, Effendi MH, Pratama BP, Ugbo EN, Budiastuti B, Helmi VN, Wibowo S, Ahmad RZ, Moses IB, Kurniawan Mâ, Rehman S, Ma'ruf IF, Utari F. Role of celery (Apium graveolens) in reducing uric acid and cholesterol in experimental animals: A literature review. Open Vet. J.. 2026; 16(6): 3861-3878. doi:10.5455/OVJ.2026.v16.i6.56


Vancouver/ICMJE Style

Ramdani D, Khairullah AR, Plumeriastuti H, Effendi MH, Pratama BP, Ugbo EN, Budiastuti B, Helmi VN, Wibowo S, Ahmad RZ, Moses IB, Kurniawan Mâ, Rehman S, Ma'ruf IF, Utari F. Role of celery (Apium graveolens) in reducing uric acid and cholesterol in experimental animals: A literature review. Open Vet. J.. (2026), [cited June 19, 2026]; 16(6): 3861-3878. doi:10.5455/OVJ.2026.v16.i6.56


Harvard Style

Ramdani, D., Khairullah, . A. R., Plumeriastuti, . H., Effendi, . M. H., Pratama, . B. P., Ugbo, . E. N., Budiastuti, . B., Helmi, . V. N., Wibowo, . S., Ahmad, . R. Z., Moses, . I. B., Kurniawan, . M. â., Rehman, . S., Ma'ruf, . I. F. & Utari, . F. (2026) Role of celery (Apium graveolens) in reducing uric acid and cholesterol in experimental animals: A literature review. Open Vet. J., 16 (6), 3861-3878. doi:10.5455/OVJ.2026.v16.i6.56


Turabian Style

Ramdani, Dewi, Aswin Rafif Khairullah, Hani Plumeriastuti, Mustofa Helmi Effendi, Bima Putra Pratama, Emmanuel Nnabuike Ugbo, Budiastuti Budiastuti, Vitra Nuraini Helmi, Syahputra Wibowo, Riza Zainuddin Ahmad, Ikechukwu Benjamin Moses, Muhammad ‘ahdi Kurniawan, Saifur Rehman, Ilma Fauziah Ma'ruf, and Fadhila Utari. 2026. Role of celery (Apium graveolens) in reducing uric acid and cholesterol in experimental animals: A literature review. Open Veterinary Journal, 16 (6), 3861-3878. doi:10.5455/OVJ.2026.v16.i6.56


Chicago Style

Ramdani, Dewi, Aswin Rafif Khairullah, Hani Plumeriastuti, Mustofa Helmi Effendi, Bima Putra Pratama, Emmanuel Nnabuike Ugbo, Budiastuti Budiastuti, Vitra Nuraini Helmi, Syahputra Wibowo, Riza Zainuddin Ahmad, Ikechukwu Benjamin Moses, Muhammad ‘ahdi Kurniawan, Saifur Rehman, Ilma Fauziah Ma'ruf, and Fadhila Utari. "Role of celery (Apium graveolens) in reducing uric acid and cholesterol in experimental animals: A literature review." Open Veterinary Journal 16 (2026), 3861-3878. doi:10.5455/OVJ.2026.v16.i6.56


MLA (The Modern Language Association) Style

Ramdani, Dewi, Aswin Rafif Khairullah, Hani Plumeriastuti, Mustofa Helmi Effendi, Bima Putra Pratama, Emmanuel Nnabuike Ugbo, Budiastuti Budiastuti, Vitra Nuraini Helmi, Syahputra Wibowo, Riza Zainuddin Ahmad, Ikechukwu Benjamin Moses, Muhammad ‘ahdi Kurniawan, Saifur Rehman, Ilma Fauziah Ma'ruf, and Fadhila Utari. "Role of celery (Apium graveolens) in reducing uric acid and cholesterol in experimental animals: A literature review." Open Veterinary Journal 16.6 (2026), 3861-3878. Print. doi:10.5455/OVJ.2026.v16.i6.56


APA (American Psychological Association) Style

Ramdani, D., Khairullah, . A. R., Plumeriastuti, . H., Effendi, . M. H., Pratama, . B. P., Ugbo, . E. N., Budiastuti, . B., Helmi, . V. N., Wibowo, . S., Ahmad, . R. Z., Moses, . I. B., Kurniawan, . M. â., Rehman, . S., Ma'ruf, . I. F. & Utari, . F. (2026) Role of celery (Apium graveolens) in reducing uric acid and cholesterol in experimental animals: A literature review. Open Veterinary Journal, 16 (6), 3861-3878. doi:10.5455/OVJ.2026.v16.i6.56


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