Open Veterinary Journal

Open Veterinary Journal

Peer-Reviewed Journal 
ISSN 2218-6050 (Online), ISSN 2226-4485 (Print) 

Renal adenocarcinoma-associated erythrocytosis in a cat: clinicopathological features and immunohistochemical results

Roberta Troia(1,*), Chiara Agnoli(1), Federico Fracassi(1), Giuliano Bettini(1), Alessandra Sfacteria(2), Luciano Pisoni(1) and Francesco Dondi(1)

Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, Italy

2 Department of Veterinary Sciences, University of Messina, Italy



This report documents a case of secondary inappropriate erythrocytosis in a cat with renal cell adenocarcinoma, its stabilization through manual erythrocytapheresis, and the EPO-immunostaining on the affected kidney. An 11-year-old cat was presented with lethargy, weight loss and polyuria/polydipsia. An abdominal mass was detected upon physical examination. Clinicopathological work-up revealed marked erythrocytosis (HCT value 64.8%), renal azotemia and decreased urine specific gravity (USG). An abdominal ultrasound was performed, localizing the mass in the right kidney. Serum erythropoietin (EPO) was above the reference interval (RI), and the cytology of the mass was indicative of renal carcinoma. Manual erythrocytapheresis was performed in order to stabilize the patient before surgery, improving the cat’s clinical and clinicopathological condition. After nephrectomy, EPO and creatinine concentrations returned within the RI, while the USG markedly increased. Histopathology confirmed the diagnosis of renal adenocarcinoma. Immunohistochemistry with anti-EPO antibody revealed diffuse and strong cytoplasmatic positivity in tumor cells.

Keywords: Erythropoietin, Feline, Immunohistochemistry, Manual erythrocytapheresis, Renal neoplasia.


Cite this paper:

Troia, R., Agnoli, C., Fracassi, F., Bettini, G., Sfacteria, A., Pisoni, L. and Dondi, F. 2017. Renal adenocarcinoma-associated erythrocytosis in a cat: clinicopathological features and immunohistochemical results. Open Vet. J. 7(4), 294-299.