Open Veterinary Journal

Open Veterinary Journal

Peer-Reviewed Journal 
ISSN 2218-6050 (Online), ISSN 2226-4485 (Print) 

"Case Report"

Long-term management of a cat with nasopharyngeal lymphoma by chlorambucil

Kaho Takahashi(1), Takashi Baba(1), Marin Hirokawa(1), Masaki Miyajima(1), Miori Kishimoto(1), Junpei Kimura(2), Hirotaka Kondo(3) and Keitaro Ohmori(1*)

1- Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan

2- College of Veterinary Medicine and Research Institute for Veterinary Medicine, Seoul National University, Seoul, South Korea

3- Laboratory of Veterinary Pathology, College of Bioresource Sciences, Nihon University, Kanagawa, Japan


Background: Lymphoma in the nasal cavity is the most common tumor of cats' upper respiratory tract. However, the effect of single-agent chlorambucil on nasal or nasopharyngeal lymphoma has not been evaluated in cats.

Case Description: An 8-year-old, castrated male Scottish Fold weighing 3.5 kg presented with an 8-month history of nasal discharge, sneezing, and mild epistaxis. CT and rhinoscopy revealed nasal discharge and slight swelling of the nasopharyngeal mucosa, but no masses and local invasions were detected. Histopathological and immunohistochemical analyses of the nasopharyngeal mucosa demonstrated B-cell lymphoma in the cat. The treatment with chlorambucil led to long-term management of the cat without any side effects. No recurrences of clinical signs have been observed for 754 days.

Conclusion: The present case report suggests that chlorambucil can be a therapeutic option for feline localized nasopharyngeal B-cell lymphoma without masses and local invasions.

Keywords: Cat, Chlorambucil, Lymphoma, Nasal cavity, Nasopharynx.

Cite this paper:

Takahashi, K., Baba, T., Hirokawa, M., Miyajima, M., Kishimoto, M., Kimura, J., Kondo, H. and Ohmori, K. 2021. Long-term management of a cat with nasopharyngeal lymphoma by chlorambucil. Open Vet. J. 11(2), 217-221.