Open Veterinary Journal

Open Veterinary Journal

Peer-Reviewed Journal 
ISSN 2218-6050 (Online), ISSN 2226-4485 (Print) 

Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare


Enrico Pierluigi Spugnini(1,2,*), Carlo Bolaffio(2), Licia Scacco(2) and Alfonso Baldi(1,3)


Biopulse S.r.l., Naples, Italy

Equivet Roma Hospital, Rome, Italy

Department of Environmental, Biological and Pharmaceutical Sciences and Technologies Campania University “Luigi Vanvitelli”, Caserta, Italy

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Abstract

A twenty-year-old female saddle horse was referred for evaluation of a seven month, non-healing erosive lesion of the right hind hoof with proliferation and bleeding of the underlying soft tissues. This lesion had been twice surgically treated as a canker but rapidly recurred. Histological examination of the second excision revealed a well-differentiated squamous cell carcinoma. At presentation, the horse was mildly depressed, lame and partially non-weight-bearing on the right hind leg, which exhibited a 10 x 10 cm erosive and proliferative lesion remodeling the hoof. After completing staging procedures, the lesion was approached with surgery and intraoperative electrochemotherapy (ECT) administration of bleomycin in isolated limb perfusion. A second session of surgery and ECT was performed one month later, followed by three additional monthly sessions of ECT. During periodic recheck, the mare showed continuous improvement. One year after presentation, the mare was in complete remission and her gait markedly improved. ECT was well-tolerated and resulted in improved local control of a tumor in a challenging anatomical district.

Key words: Bleomycin, Electrochemotherapy, Equine, Hoof, Squamous cell carcinoma.

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Cite this paper:

Spugnini, E.P., Bolaffio, C., Scacco, L. and Baldi, A. 2017. Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare. Open Vet. J. 7(2), 192-196.