Open Veterinary Journal

Open Veterinary Journal

Peer-Reviewed Journal 
ISSN 2218-6050 (Online), ISSN 2226-4485 (Print) 

"Original Research"

Suppression of reproductive function in juvenile rams by a slow-release gonadotropin-releasing hormone implant


Luise Prestel(1), Jessica Joerling(2), Klaus Failing(3), Henrik Wagner(1) and Axel Wehrend(1*)


1- Clinic for Obstetrics, Gynaecology, and Andrology of Large and Small Animals, Justus Liebig University Giessen, Frankfurter Straße 106, 35392 Giessen, Germany

2- Clinic for Ruminants, Justus Liebig University Giessen, Frankfurter Straße 104, 35392 Giessen, Germany

3- Biomathematics and Data Processing Group, Justus Liebig University Giessen, Frankfurter Straße 95, 35392 Giessen, Germany

Abstract

Background: Regarding animal welfare and reversible suppression of reproduction the need for alternatives to surgical castration like slow-release gonadotropin-releasing hormone implants is increasing.

Aim: In this study, we evaluated whether the onset of puberty can be suppressed by implantation of a slow-release gonadotropin-releasing hormone implant (4.7 mg deslorelin) in juvenile rams.

Methods: Seven juvenile rams (3-5.5 months) were treated with the gonadotropin-releasing hormone analogue deslorelin to analyse the effects on testicular development, sonographic findings of testicular tissue, testosterone concentration in the blood, spermatogenesis and sperm parameters from the epididymis after castration. Seven rams of the same age without an implant served as controls.

Results: Follow-up examinations were performed over five months, after which four rams per group were castrated. No significant group differences were found in the andrological parameters on the group level, but testicular development was suppressed in three rams in the treated group. Histological examination revealed spermatogenesis in the testicular tissue in three of four animals treated with a gonadotropin-releasing hormone analogue.

Conclusion: The onset of puberty in juvenile rams cannot be reliably suppressed by using the slow-release gonadotropin-releasing hormone implant Suprelorin®.

Keywords: Castration, Male, Hormonal downregulation, Puberty, Sheep.
Cite this paper:
Prestel, L., Joerling, J., Failing, K., Wagner, H. and Wehrend, A. 2022. Suppression of reproductive function in juvenile rams by a slow-release gonadotropin-releasing hormone implant. Open Vet. J. 12(2), 171-181.