Open Veterinary Journal

Open Veterinary Journal

Peer-Reviewed Journal 
ISSN 2218-6050 (Online), ISSN 2226-4485 (Print) 

"Case Report"

A long survival case of spinal nephroblastoma in a dog


Munekazu Nakaichi(1*), Toshie Iseri(1), Hiro Horikirizono(1), Harumichi Itoh(2), Hiroshi Sunahara(3), Yuki Nemoto(3), Kazuhito Itamoto(2) and Kenji Tani(3)


1- Department of Veterinary Radiology, Joint Faculty of Veterinary Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, Yamaguchi 753-8515, Japan

2- Department of Veterinary Small Animal Clinical Science, Joint Faculty of Veterinary Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, Yamaguchi 753-8515, Japan

3- Department of Veterinary Surgery, Joint Faculty of Veterinary Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, Yamaguchi 753-8515, Japan

Abstract

Background: dogs' nephroblastoma of the spinal cord is a rare neoplastic disease, with few reports of long-term survival after surgery. We experienced that surgical treatment with postoperative radiation therapy for spinal nephroblastoma in a dog resulted in the long-term survival of 11 years.

Case Description: The patient presented to our veterinary hospital because of progressive hindlimb paralysis. Based on diagnostic imaging, she was diagnosed with a thoracolumbar spinal cord tumour and was treated with surgery. The gross tumour tissue was removed after laminectomy, followed by postoperative radiation therapy using orthovoltage equipment. The histopathological features of the surgical specimen were consistent with those of previously reported spinal nephroblastoma, although infrequent mitotic figures were observed. The dog recovered well after treatment and resumed her normal walking condition.No tumour recurrence was observed on periodic follow-up magnetic resonance imaging performed 10 and 21 months after surgery. Imaging evaluation for the gradual development of hindlimb weakness was performed 9 years after surgery; however, no recurrence of tumour tissue was observed, and spondylosis deformans, probably induced after laminectomy, were identified as a possible cause. The dog died of aspiration pneumonia 11 years after surgery, independent of spinal nephroblastoma.

Conclusion: To date, no clinical cases of canine spinal cord primary nephroblastoma that survived for 11 years after surgery have been reported. This case strongly suggests that providing intensive treatment for canine spinal nephroblastoma is very important.

Keywords: Dog, Nephroblastoma, Radiation, Spinal cord, Surgery.

Cite this article:
Nakaichi, M., Iseri, T., Horikirizono, H., Itoh, H., Sunahara, H., Nemoto, Y., Itamoto, K. and Tani, K. 2022. A long survival case of spinal nephroblastoma in a dog. Open Vet. J. 12(2), 188-191.