Open Veterinary Journal

Open Veterinary Journal

Peer-Reviewed Journal 
ISSN 2218-6050 (Online), ISSN 2226-4485 (Print) 

"Case Report"

Electrochemotherapy for the treatment of an incompletely excised subcutaneous low grade epithelioid hemangioendothelioma in a budgerigar parakeet (Melopsittacus undulatus)


Andrea Lanza(1), Alfonso Baldi(2), Giacomo Rossi(3) and Enrico Pierluigi Spugnini(4*)


1- Centro Veterinario Gianicolense, Via Lorenzo Valla, 25, Rome, Italy

2- Department of Environmental, Biological and Pharmaceutical Sciences and Technologies Campania University "Luigi Vanvitelli", Caserta, Italy

3- School of Biosciences & Veterinary Medicine, Matelica (MC), University of Camerino, Italy

4- Biopulse srl, Via Toledo 256 Naples, Italy

Abstract:

Background: Cutaneous tumors are rarely described in avians, and are frequently of viral origin. Solid tumors of vascular origin are seldom reported and usually result in a difficult management by surgery alone. We describe the outcome of a subcutaneous low grade epithelioid hemangioendothelioma treated with the combination of surgery and electrochemotherapy.

Case Description: A ten-year-old male budgerigar parakeet (Melopsittacus undulatus) was referred for evaluation of a 2-month nonhealing exophytic mass on the left wing. The bird was bright, alert, and responsive, with a 2 X 1 cm proliferative lesion on the wing. Signs of discomfort were elicited by the clinical manipulation of the wing; no other abnormalities were detected during physical evaluation. Following hematological and imaging analysis, the parakeet was anesthetized and the mass was surgically removed. The histopathology report came back with a diagnosis of incompletely excised subcutaneous low grade epithelioid hemangioendothelioma. A surgical revision was not feasible due to the anatomical location and tumor extension. Adjuvant electrochemotherapy was chosen to increase the chance of tumor control. Two sessions of electrochemotherapy were performed with a 2-week interval between treatments using intralesional bleomycin followed by trains of permeabilizing electric pulses. Side effects were not observed and the parakeet was disease free for 12 months, when he died of acute renal failure.

Conclusion: In lieu of the incomplete surgical excision of the tumor, electrochemotherapy resulted in good local control and cosmetic appearance and should be added to the standard oncological therapies for avian.

Keywords: Avian, Biphasic electric pulses, Bleomycin, Electrochemotherapy, Parakeet.

Cite this paper:

Lanza, A., Baldi, A., Rossi, G. and Spugnini, E.P. 2019. Electrochemotherapy for the treatment of an incompletely excised subcutaneous low grade epithelioid hemangioendothelioma in a budgerigar parakeet (Melopsittacus undulatus). Open Vet. J. 9(3), 269-272.