Chlorpyrifos chronic toxicity in broilers and effect of vitamin C
A.M. Kammon1,*, R.S. Brar2, S. Sodhi2, H.S. Banga2, J. Singh3 and N.S. Nagra4
1Department of Poultry and Fish Diseases, Faculty of Veterinary Medicine, Al-Fateh University, Tripoli, Libya
2Department of Veterinary Pathology, College of Veterinary Science, GADVASU, Ludhiana, India
3Department of Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Canada
4Department of Livestock Production and Management, College of Veterinary Science, GADVASU, Ludhiana, India
An experiment was conducted to study chlorpyrifos chronic toxicity in broilers and the protective effect of vitamin C. Oral administration of 0.8 mg/kg body weight (bw) (1/50 LD50) chlorpyrifos (Radar®), produced mild diarrhea and gross lesions comprised of paleness, flaccid consistency and slightly enlargement of liver. Histopathologically, chlorpyrifos produced degenerative changes in various organs. Oral administration of 100 mg/kg bw vitamin C partially ameliorated the degenerative changes in kidney and heart. There was insignificant alteration in biochemical and haematological profiles. It is concluded that supplementation of vitamin C reduced the severity of lesions induced by chronic chlorpyrifos toxicity in broilers.
Keywords: chlorpyrifos, chronic toxicity, clinicopathology, vitamin C, broilers.
Cite this paper:
Kammon, A.M., Brar, R.S., Sodhi, S., Banga, H.S, Singh, J. and Nagra, N.S. 2011. Chlorpyrifos chronic toxicity in broilers and effect of vitamin C. Open Vet. J. 1, 21-27.