Open Veterinary Journal

Open Veterinary Journal

Peer-Reviewed Journal 
ISSN 2218-6050 (Online), ISSN 2226-4485 (Print) 

"Original Research"

Effects of fake and original perfumes on the presence, numbers, and distribution of mast cells in selected tissues in rats


Wael M. Hananeh(1*), Fatima Al Ghbari(1), Raida Al Rukibat(1), Mohammad Al Zghoul(2) and Zuhair Bani Ismail(3)


1- Department of Veterinary Pathology and Public Health. Faculty of Veterinary Medicine, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan

2- Department of Basic Veterinary Medical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan

3- Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan

Abstract

Background: Perfumes, whether original or fake, are considered of great economic value. However, overzealous use of perfumes could be associated with local or systemic side effects.

Aim: This study was conducted to investigate the effects of daily use of original and fake perfumes on numbers and distribution of mast cells in several organs and tissues of Wistar rats.

Methods: Three different kinds of original perfumes coded as O1, O2, and O3 and their fake counterparts coded as F1, F2, and F3 were applied once daily directly on the skin of rats for 28 consecutive days. At the end of the study, representative tissue samples were taken and processed for histopathological examination using Hematoxylin and Eosin, toluidine blue, and Wright’s stains.

Results: A significant (p < 0.05) elevation in mast cell count was observed in F3, O3, F1, and F2 compared to the control group. The majority of mast cells were distributed in the hepatic perivascular tissues, peribronchial and pleural tissues. There was a significant (p < 0.05) elevation in mast cell count in along the interalveolar wall, peribronchial area, and pleura tissues in F1 and O3 groups.

Conclusion: Results of this study indicated that repeated use of both original and fake perfumes was associated with an increased number of mast cells in different body organs and tissues.

Keywords: Perfumes, Fake, Original, Mast cells, Histopathology.

Cite this paper:
Hananeh, W.M., Al Ghbari, F., Al Rukibat, R., Al Zghoul, M. and Ismail, Z.B. 2021. Effects of fake and original perfumes on the presence, numbers, and distribution of mast cells in selected tissues in rats. Open Vet. J. 11(2), 277-282.