Raquel de Araújo Cantarella(1), Juliana Kravetz de Oliveira(1), Daniel M. Dorbandt(2,3) and Fabiano Montiani-Ferreira(1,*)
1 Universidade Federal do Paraná (UFPR), Departamento de Medicina Veterinária, Rua dos Funcionários, 1540, Bairro Juvevê, 80035-050, Curitiba – PR, Brazil
2 Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 1008, West Hazelwood Drive, Urbana, Illinois 61802, USA
3 Central Hospital for Veterinary Medicine, North Haven, Connecticut 06473, USA
To evaluate corneal sensitivity by using the Cochet-Bonnet® esthesiometer in normal canine eyes at different time points following instillation of three different topical non-steroidal anti-inflammatory drugs (flurbiprofen sodium 0.03%, diclofenac sodium 0.1% and ketorolac tromethamine 0.5%) and benzalkonium chloride 0.01%. Six healthy mixed breed dogs from the same litter were used in two different stages. First, one drop of flurbiprofen sodium 0.03% and diclofenac sodium 0.1% in each eye; second, one drop of ketorolac tromethamine 0.5% and benzalkonium chloride 0.01% in each eye. Baseline esthesiometry was obtained before eye drop application and every 15 minutes thereafter until a total of 105 minutes of evaluation time. A one-week interval was allowed between the two treatment phases. Statistical analysis was used to compare means according to time of evaluation and drug used. Diclofenac sodium 0.1% decreased corneal sensitivity at 75 and 90 minutes (P > 0.015) with possible interference on neuronal nociceptive activity and analgesic effect while ketorolac tromethamine 0.5% did not show any variation for esthesiometry means along the evaluation. Flurbiprofen sodium 0.03% resulted in increased esthesiometry values 30 minutes after instillation (P > 0.013), increasing corneal sensitivity and possibly producing a greater irritant corneal effect over its analgesic properties. Benzalkonium chloride 0.01% significantly increased corneal sensitivity at 15 minutes of evaluation (P > 0.001), most likely resulting from its irritating effect. Esthesiometry did not allow a definite conclusion over the analgesic effect of the NSAIDs tested; however it was effective in detecting fluctuations in corneal sensitivity.
Keywords: Cochet-Bonnet, Cornea, Nociceptors, NSAID.
Cite this paper:
Cantarella, R.A., de Oliveira, J.K., Dorbandt, D.M. and Montiani-Ferreira, F. 2017. Effects
of topical flurbiprofen sodium, diclofenac sodium, ketorolac tromethamine and
benzalkonium chloride on corneal sensitivity in normal dogs. Open Vet. J. 7(3), 254-260.