Open Veterinary Journal

Peer-Reviewed Journal


E.A. Soler Arias(1,*), V.A. Castillo(1), R.H. Trigo(2) and M.E. Caneda Aristarain(3)


1 Hospital Escuela, Unidad de Endocrinología, Area de Clínica Médica de Pequeños Animales, Fac. de Ciencias Veterinarias, UBA, Av. Chorroarín 280, Ciudad Autónoma de Buenos Aires, Argentina

2 Catedra de Patología, Fac. de Ciencias Veterinarias, UBA, Av. Chorroarín 280, Ciudad Autónoma de

Buenos Aires, Argentina

3 Alumna de Programa de Investigación. Fac. de Ciencias Veterinarias, UBA, Chorroarín 280, Ciudad Autónoma de Buenos Aires, Argentina

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Abstract

Human multiple endocrine neoplasia subtype 2A (MEN 2A) is characterized by medullary thyroid carcinoma, pheochromocytoma and parathyroid hyperplasia or adenoma in the same individual. In this report, a case of a female Rottweiler with medullary thyroid carcinoma, bilateral pheochromocytoma and parathyroid adenoma was described. Clinical manifestations of muscle weakness, polydipsia, polyuria, diarrhea and weight loss were observed. Two adrenal neoplasms were identified incidentally by ultrasonography, and tumor in the left thyroid lobe was identified by palpation. Primary hyperparathyroidism was diagnosed by biochemical testing. Histopathology report was consistent with diagnosis of bilateral pheochromocytoma and parathyroid adenoma. Immunohistochemical staining was positive for calcitonin and synaptophysin, and negative for thyroglobulin, which confirmed medullary thyroid carcinoma. This case in a dog is presenting neoplastic characteristics similar to human MEN 2A and emphasizing the importance of using immunohistochemistry for confirmation.

Keywords: Calcitonin, Immunohistochemistry, MEN 2A, Synaptophysin, Thyroglobulin.

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Cite this paper:
Soler Arias, E.A., Castillo, V.A., Trigo, R.H. and Caneda Aristarain, M.E. 2016. Multiple endocrine neoplasia similar to human subtype 2A in a dog: Medullary thyroid carcinoma, bilateral pheochromocytoma and parathyroid adenoma. Open Vet. J. 6(3), 165-171.