Open Veterinary Journal

Peer-Reviewed Journal

First report of cerebellar abiotrophy in an Arabian foal from Argentina

 

S.A. Sadaba(1,2), G.J. Madariaga(3), C.M. Corbi Botto(1,2), M.H. Carino(1), M.E. Zappa(1), P. Peral García(1), S.A. Olguín(4), A. Massone(3) and S. Díaz(1,*)

 

1 IGEVET – Instituto de Genética Veterinaria “Ing. Fernando Noel Dulout” (UNLP-CONICET La Plata), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina

2 Research Fellows from Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Av. Rivadavia 1917 (C1033AAJ) CABA, Argentina

3 Laboratorio de Patología Especial Veterinaria, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina

4 Cátedra de Métodos Complementarios de Diagnóstico, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina

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Abstract

Evidence of cerebellar abiotrophy (CA) was found in a six-month-old Arabian filly with signs of incoordination, head tremor, wobbling, loss of balance and falling over, consistent with a cerebellar lesion. Normal hematology profile blood test and cerebrospinal fluid analysis excluded infectious encephalitis, and serological testing for Sarcocystis neurona was negative. The filly was euthanized. Postmortem X-ray radiography of the cervical cephalic region identified not abnormalities, discounting spinal trauma. The histopathological analysis of serial transverse cerebellar sections by electron microscopy revealed morphological characteristics of apoptotic cells with pyknotic nuclei and degenerate mitochondria, cytoplasmic condensation and areas with absence of Purkinje cells, matching with CA histopathological characteristics. The indirect DNA test for CA was positive in the filly, and DNA test confirmed the CA carrier state in the parents and the recessive inheritance of the disease. To our knowledge this is the first report of a CA case in Argentina.

Keywords: Apoptosis, Arabian horses, Cerebellar abiotrophy, DNA, Purkinje cells.

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Cite this paper:
Sadaba, S.A., Madariaga, G.J., Corbi Botto, C.M., Carino, M.H., Zappa, M.E., Peral García, P., Olguín, S.A., Massone, A. and Díaz, S. 2016. First report of cerebellar abiotrophy in an Arabian foal from Argentina. Open Vet. J. 6(3), 259-262.