Open Veterinary Journal

Peer-Reviewed Journal

Exploiting serological data to understand the epidemiology of foot-and-mouth disease virus serotypes circulating in Libya

 

Ibrahim Eldaghayes(1,*), Abdunaser Dayhum(1), Abdulwahab Kammon(1), Monier Sharif(2), Giancarlo Ferrari(3), Christianus Bartels(4), Keith Sumption(4), Donald P. King(5), Santina Grazioli(6) and Emiliana Brocchi(6)

 

1 Faculty of Veterinary Medicine, University of Tripoli, P. O. Box 13662, Tripoli, Libya

2 Faculty of Veterinary Medicine, University of Omar Al-Mukhtar, Albeida, Libya

3 Food and Agriculture Organization of the United Nations (FAO), Rome, Italy

4 European Commission for the Control of Foot-and-Mouth Disease (EuFMD), Food and Agriculture Organization of the United Nations (FAO), Rome, Italy

5 The Pirbright Institute, Ash Road, Surrey, UK

6 Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna (IZSLER), Brescia, Italy

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Abstract

Sporadic outbreaks of foot-and-mouth disease (FMD) have occurred in Libya for almost fifty years. During the spring of 2013, a countrywide serosurvey was undertaken to assess the level of FMD virus circulation and identify FMD virus serotypes in the country. A total of 4221 sera were collected, comprising samples from large ruminants (LR; n=1428 samples from 357 farms) and small ruminants (SR; n=2793 samples from 141 farms). FMD sero-prevalence of NSP antibodies determined by ELISA were 19.0% (271/1428) with 95% CI (16.9 – 21.0) and 13.5% (378/2793) with 95% CI (12.3 – 14.8) for LR and SR samples, respectively. The sero-prevalence of NSP antibodies in LR was 12.3% and 19.8% for age group < 1 year and ≥ 1 year, respectively (X2= 4.95, P= 0.026), while in SR was 3.7%, 13.6% and 21.3% for age group < 1 year, 1-2 year and > 2 year, respectively (X2= 118.1, P= 0.000). These observed NSP serologic profiles support the hypothesis of an endemic level of FMD circulation in Libya. All positive sera were tested for SP antibodies for O, A and SAT-2 FMD virus serotypes. Serotype O was the dominant circulating serotype followed by serotype A, while evidence of SAT-2 was not found. These data provide an insight into the wider epidemiology of FMD in Libya, and contribute to field and laboratory investigations that during 2013 serotype O (O/ME-SA/Ind-2001 lineage) was isolated from clinical samples collected from the country.

Keywords: Foot-and-mouth disease, Large ruminants, Libya, Sero-prevalence, Small ruminants.

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Cite this paper:
Eldaghayes, I., Dayhum, A., Kammon, A., Sharif, M., Ferrari, G., Bartels, C., Sumption, K., King, D.P., Grazioli, S. and Brocchi, E. 2017. Exploiting serological data to understand the epidemiology of foot-and-mouth disease virus serotypes circulating in Libya. Open Vet. J. 7(1), 1-11.